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MedKoo Cat#: 574372 | Name: MCL-0020

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MCL-0020 is a selective melanocortin MC4 receptor antagonist that significantly reverses stress-induced anorexia but has no effect on food intake in free-feeding rats. MCL-0020 exhibits anxiolytic-like activity in vivo.

Chemical Structure

MCL-0020
MCL-0020
CAS#475498-26-1

Theoretical Analysis

MedKoo Cat#: 574372

Name: MCL-0020

CAS#: 475498-26-1

Chemical Formula: C34H39N7O4

Exact Mass: 609.3064

Molecular Weight: 609.73

Elemental Analysis: C, 66.98; H, 6.45; N, 16.08; O, 10.50

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Related CAS #
475498-26-1 MCL0020 (trifluoroacetate salt)
Synonym
MCL-0020, MCL 0020, MCL0020
IUPAC/Chemical Name
(S)-2-((R)-2-acetamido-3-(naphthalen-2-yl)propanamido)-N-((R)-1-amino-3-(naphthalen-2-yl)-1-oxopropan-2-yl)-5-guanidinopentanamide
InChi Key
FJFLYSMWSRRMRO-FRXPANAUSA-N
InChi Code
InChI=1S/C34H39N7O4/c1-21(42)39-30(20-23-13-15-25-8-3-5-10-27(25)18-23)33(45)40-28(11-6-16-38-34(36)37)32(44)41-29(31(35)43)19-22-12-14-24-7-2-4-9-26(24)17-22/h2-5,7-10,12-15,17-18,28-30H,6,11,16,19-20H2,1H3,(H2,35,43)(H,39,42)(H,40,45)(H,41,44)(H4,36,37,38)/t28-,29+,30+/m0/s1
SMILES Code
CC(=O)N[C@H](CC1=CC2=CC=CC=C2C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC1=CC2=CC=CC=C2C=C1)C(N)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble to 2 mg/ml in 25% ethanol / water
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
MCL0020 is a potent and selective melanocortin MC4 receptor antagonist, with an IC50 of 11.63 nM.
In vitro activity:
In addition, MCL0020 significantly attenuated the cAMP formation induced by alpha-MSH in COS-1 cells expressing the melanocortin MC4 receptor without affecting basal cAMP contents. Reference: Eur J Pharmacol. 2003 Aug 1;474(1):95-101. https://pubmed.ncbi.nlm.nih.gov/12909200/
In vivo activity:
Restraint stress significantly reduced food intake in rats, and i.c.v. administration of MCL0020 dose-dependently and significantly attenuated restraint stress-induced anorexia without affecting food intake. Swim stress induced reduction in the time spent in the light area in the mouse light/dark exploration test, and MCL0020 significantly prevented it. Reference: Eur J Pharmacol. 2003 Aug 1;474(1):95-101. https://pubmed.ncbi.nlm.nih.gov/12909200/

Preparing Stock Solutions

The following data is based on the product molecular weight 609.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
Chaki S, Ogawa S, Toda Y, Funakoshi T, Okuyama S. Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents. Eur J Pharmacol. 2003 Aug 1;474(1):95-101. doi: 10.1016/s0014-2999(03)02033-8. PMID: 12909200.
In vitro protocol:
Chaki S, Ogawa S, Toda Y, Funakoshi T, Okuyama S. Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents. Eur J Pharmacol. 2003 Aug 1;474(1):95-101. doi: 10.1016/s0014-2999(03)02033-8. PMID: 12909200.
In vivo protocol:
Chaki S, Ogawa S, Toda Y, Funakoshi T, Okuyama S. Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents. Eur J Pharmacol. 2003 Aug 1;474(1):95-101. doi: 10.1016/s0014-2999(03)02033-8. PMID: 12909200.
Chaki et al (2003) Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents. Eur.J.Pharmacol. 474 95 PMID: 12909200