Synonym
Promazine Hydrochloride; Promazine Hcl; Starazin; Talofen; Promazine monohydrochloride; Hydrochloride, Promazine ; Promazine ; Promazine Hydrochloride; Protactyl; Sinophenin; Sparine;
IUPAC/Chemical Name
N,N-dimethyl-3-phenothiazin-10-ylpropan-1-amine;hydrochloride
InChi Key
JIVSXRLRGOICGA-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H20N2S.ClH/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19;/h3-6,8-11H,7,12-13H2,1-2H3;1H
SMILES Code
CN(C)CCCN1C2=CC=CC=C2SC3=CC=CC=C31.Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
320.88
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Terdale SS, Dagade DH, Patil KJ. Thermodynamic studies of
drug-alpha-cyclodextrin interactions in water at 298.15 K: promazine
hydrochloride/chlorpromazine hydrochloride + alpha-cyclodextrin + H(2)O systems.
J Phys Chem B. 2007 Dec 6;111(48):13645-52. Epub 2007 Nov 8. PubMed PMID:
17988113.
2: Pusateri FM, Hibler CP, Pojar TM. Oral administration of diazepam and
promazine hydrochloride to immobilize pronghorn. J Wildl Dis. 1982
Jan;18(1):9-16. PubMed PMID: 7097876.
3: Coffman JR, Bracken WJ. Promazine hydrochloride in endotoxin shock in a horse.
(A case report). Vet Med Small Anim Clin. 1968 Oct;63(10):963-6. PubMed PMID:
5188322.
4: Regan AG, Aldrete JA. Prolonged apnea after administration of promazine
hydrochloride following succinylcholine infusion: a case report. Anesth Analg.
1967 May-Jun;46(3):315-8. PubMed PMID: 6067266.
5: Buenello ED, Zamel N. [Comparative effect of chlordiazepoxide and promazine
hydrochloride in the treatment of delirium tremens]. Folha Med. 1965
Oct;51(4):339-42. Portuguese. PubMed PMID: 5852568.
6: ZOURLAS PA. IN VITRO AND IN VIVO EFFECTS OF SPARINE (PROMAZINE HYDROCHLORIDE)
ON HUMAN UTERINE CONTRACTILITY. Am J Obstet Gynecol. 1964 Mar 15;88:770-3. PubMed
PMID: 14130340.
7: EVANS RD. The successful management of a case of neonatal tetanus using
paraldehyde and promazine hydrochloride (sparine) for sedation. Arch Pediatr.
1962 Aug;79:299-301. PubMed PMID: 13891009.
8: ROLO A. Drug withdrawal with promazine hydrochloride. N Y State J Med. 1962
May 1;62:1429-31. PubMed PMID: 14493509.
9: van LEEUWEN D, SCHOLL FS. [Promazine hydrochloride (Prazine) during labor].
Geneeskd Gids. 1962 Apr 19;40:161-4. Dutch. PubMed PMID: 14463635.
10: SCHYMA A. [On pre- and postoperative medication with promazine hydrochloride
(protactyl)]. Med Welt. 1960 Dec 24;52-53:2781-3. German. PubMed PMID: 13749279.
11: ALBUM MM. Dental use of meprobamate and promazine hydrochloride for mentally
retarded and emotionally disturbed patients. A preliminary report. Oral Surg Oral
Med Oral Pathol. 1960 Apr;13:423-6. PubMed PMID: 13792453.
12: AGRESTI E. [On treatment with promazine hydrochloride in chronic
psychopathics]. Rass Studi Psichiatr. 1960;49:612-8. Italian. PubMed PMID:
13681699.
13: EARLE BV. Fatal agranulocytosis due to promazine hydrochloride. Lancet. 1957
Nov 9;273(7002):925-6. PubMed PMID: 13482248.
14: KUNTZE CD, SISON P. A new adjunct to analgesia and sedation in labor;
preliminary report of results with promazine hydrochloride by intravenous
injection. Am J Obstet Gynecol. 1957 Sep;74(3):498-504. PubMed PMID: 13458245.
15: Moore EA. Reactions to I.V. Sparine (Promazine Hydrochloride). Can Med Assoc
J. 1957 Aug 1;77(3):268. PubMed PMID: 20325532; PubMed Central PMCID: PMC1824039.
16: MANGUN CW, WEBB WW. Promazine hydrochloride in the treatment of chronic
catatonic schizophrenics. J Nerv Ment Dis. 1956 Jun;123(6):553-6. PubMed PMID:
13406581.
17: Karpińska J. Simultaneous quantification of promazine hydrochloride and its
sulfoxide in pharmaceutical preparations. Anal Sci. 2001 Feb;17(2):249-53. PubMed
PMID: 11990535.
18: Kurosawa M, Nagata S, Takeda F, Mima K, Hiraga A, Kai M, Taya K. Effects of
caffeine and promazine hydrochloride on plasma catecholamines in thoroughbreds at
rest and during treadmill exercise. Equine Vet J Suppl. 1999 Jul;(30):596-600.
PubMed PMID: 10659325.
19: Dash SK, Dastidar SG, Chakrabarty AN. Antibacterial property of promazine
hydrochloride. Indian J Exp Biol. 1977 Apr;15(4):324-6. PubMed PMID: 334671.
20: Gupta BN, Moore JA, Conner GH. The use of promazine hydrochloride in Cesarean
section in the dog. Lab Anim Care. 1970 Jun;20(3):474-6. PubMed PMID: 4247046.
