MedKoo Cat#: 555749 | Name: NSC23005 free acid
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

NSC23005 is a p18INK inhibitor. NSC23005 potently promotes hematopoietic stem cell (HSC) expansion (ED50 = 5.21 nM).

Chemical Structure

NSC23005 free acid
NSC23005 free acid
CAS#6314-70-1 (free acid)

Theoretical Analysis

MedKoo Cat#: 555749

Name: NSC23005 free acid

CAS#: 6314-70-1 (free acid)

Chemical Formula: C13H17NO4S

Exact Mass: 283.0878

Molecular Weight: 283.34

Elemental Analysis: C, 55.11; H, 6.05; N, 4.94; O, 22.59; S, 11.31

Price and Availability

Size Price Availability Quantity
100mg USD 450.00 2 Weeks
200mg USD 750.00 2 Weeks
500mg USD 1,450.00 2 Weeks
1g USD 2,550.00 2 Weeks
2g USD 4,550.00 2 Weeks
5g USD 6,650.00 2 Weeks
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Synonym
NSC23005 free acid; NSC 23005; NSC-23005; p18SMI-40;
IUPAC/Chemical Name
4-(N-cyclohexylsulfamoyl)benzoic acid
InChi Key
XGOXPTXOQXHIDL-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H17NO4S/c15-13(16)10-6-8-12(9-7-10)19(17,18)14-11-4-2-1-3-5-11/h6-9,11,14H,1-5H2,(H,15,16)
SMILES Code
O=C(O)C1=CC=C(S(=O)(NC2CCCCC2)=O)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
NSC23005 is a p18INK inhibitor.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 283.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
Xie et al (2015) Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion. Sci.Rep. 5 18115 PMID: 26681454