Kosotoxin | CAS#1400-16-4 | toxin

MedKoo Cat#: 558584 | Name: Kosotoxin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Kosotoxin is a toxin from Hagenia abyssinica. It has been found to be cytotoxic against MAC tumour cells in vivo.

Chemical Structure

Kosotoxin

CAS#1400-16-4

Theoretical Analysis

MedKoo Cat#: 558584

Name: Kosotoxin

CAS#: 1400-16-4

Chemical Formula: C50H64O16

Exact Mass: 920.4200

Molecular Weight: 921.05

Elemental Analysis: C, 65.20; H, 7.00; O, 27.79

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Kosotoxin;

IUPAC/Chemical Name

4-(2,6-dihydroxy-3-isobutyryl-4-methoxy-5-methylbenzyl)-3,5-dihydroxy-2-isobutyryl-4,6-dimethylcyclohexa-2,5-dien-1-one

InChi Key

VPCGTBGMVIIERI-UHFFFAOYSA-N

InChi Code

InChI=1S/C25H32O8/c1-10(2)17(26)15-21(30)14(19(28)12(5)22(15)33-8)9-25(7)23(31)13(6)20(29)16(24(25)32)18(27)11(3)4/h10-11,28,30-32H,9H2,1-8H3

SMILES Code

Cc1c(c(c(c(c1OC)C(=O)C(C)C)O)CC2(C(=C(C(=O)C(=C2O)C(=O)C(C)C)C)O)C)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 921.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Woldemariam TZ, Fell AF, Linley PA, Bibby MC, Phillips RM. Evaluation of the anti-tumour action and acute toxicity of kosins from Hagenia abyssinica. J Pharm Biomed Anal. 1992 Aug;10(8):555-60. PubMed PMID: 1463789. 2: Lounasmaa M, Widén CJ, Huhtikangas A. Phloroglucinol derivatives of Hagenia abyssinica. II. The structure determination of kosotoxin and protokosin. Acta Chem Scand B. 1974;28(10):1200-8. PubMed PMID: 4462358. 3: Woldemariam TZ, Fell AF, Linley PA. Chromatographic and spectroscopic studies on the constituents in male and female flowers of Hagenia abyssinica. J Pharm Biomed Anal. 1990;8(8-12):859-65. PubMed PMID: 2100633.