NSC23005 sodium | CAS#1796596-46-7 | 6314-70-1 | p18INK inhibitor

MedKoo Cat#: 530373 | Name: NSC23005 sodium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NSC23005 is a p18INK inhibitor. NSC23005 potently promotes hematopoietic stem cell (HSC) expansion (ED50 = 5.21 nM).

Chemical Structure

NSC23005 sodium

CAS#1796596-46-7 (sodium)

Theoretical Analysis

MedKoo Cat#: 530373

Name: NSC23005 sodium

CAS#: 1796596-46-7 (sodium)

Chemical Formula: C13H16NNaO4S

Exact Mass: 0.0000

Molecular Weight: 305.32

Elemental Analysis: C, 51.14; H, 5.28; N, 4.59; Na, 7.53; O, 20.96; S, 10.50

Price and Availability

Size	Price	Availability
200mg	USD 650.00	2 Weeks
500mg	USD 1,450.00	2 Weeks
1g	USD 2,450.00	2 Weeks
2g	USD 4,250.00	2 Weeks

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Related CAS #

1796596-46-7 (sodium) 6314-70-1 (free acid)

Synonym

p18SMI-40; NSC23005 sodium; NSC23005; NSC-23005; NSC 23005.

IUPAC/Chemical Name

Sodium 4-(N-cyclohexylsulfamoyl)benzoate

InChi Key

MLHFBDVMTRIQMW-UHFFFAOYSA-M

InChi Code

InChI=1S/C13H17NO4S.Na/c15-13(16)10-6-8-12(9-7-10)19(17,18)14-11-4-2-1-3-5-11;/h6-9,11,14H,1-5H2,(H,15,16);/q;+1/p-1

SMILES Code

O=C([O-])C1=CC=C(S(=O)(NC2CCCCC2)=O)C=C1.[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Related CAS# CAS#1796596-46-7 (NSC23005 sodium) CAS#6314-70-1 (NSC23005)

Product Data

Product Data

Instruction

View handling instruction

Biological target:

NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM).

In vitro activity:

TBD

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMF	0.2	0.66
	DMSO	22.8	74.67
	Ethanol	3.6	11.79
	PBS (pH 7.2)	10.0	32.75
	Water	80.5	263.65

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 305.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

Xie et al (2015) Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion. Sci.Rep. 5 18115 PMID: 26681454