Kojic Acid | CAS#501-30-4 | tyrosinase inhibitor

MedKoo Cat#: 561662 | Name: Kojic Acid

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Kojic Acid is a tyrosinase inhibitor. It is a chelation agent produced by several species of fungi, especially Aspergillus oryzae, which has the Japanese common name koji. It is a mild inhibitor of the formation of pigment in plant and animal tissues, and is used in food and cosmetics to preserve or change colors of substances. It also appears to possess marked protective (radioresistance) effects from radiation-induced damage.

Chemical Structure

Kojic Acid

CAS#501-30-4

Theoretical Analysis

MedKoo Cat#: 561662

Name: Kojic Acid

CAS#: 501-30-4

Chemical Formula: C6H6O4

Exact Mass: 142.0266

Molecular Weight: 142.11

Elemental Analysis: C, 50.71; H, 4.26; O, 45.03

Price and Availability

Size	Price	Availability	Quantity
25g	USD 250.00	2 Weeks

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Synonym

Kojic Acid;

IUPAC/Chemical Name

5-Hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

InChi Key

BEJNERDRQOWKJM-UHFFFAOYSA-N

InChi Code

InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2

SMILES Code

O=C1C=C(CO)OC=C1O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Kojic Acid is a tyrosinase inhibitor.

In vitro activity:

In addition, kojic acid could alleviate HUVEC tube formation induced by senescent HCEC, which could be reversed by p-NF-κB inhibitor. The p21 siRNA could alleviate HUVEC spheroid sprouting induced by senescent HCEC. These results indicated that kojic acid might inhibit HCEC senescence and following resulted angiogenesis via NF-κB and p21 signaling pathways, possibly through downregulation of galectin 8 and laminins. Reference: Exp Eye Res. 2019 Mar;180:174-183. https://pubmed.ncbi.nlm.nih.gov/30597146/

In vivo activity:

The results from the cytotoxicity and cell viability assays demonstrated that KA (kojic acid) could highly protect Chinese hamster ovary (CHO) cells against ionizing radiation with low toxicity. In summary, KA provides marked radioprotective effects both in vivo and in vitro. Reference: Asian Pac J Cancer Prev. 2014;15(1):291-7. https://pubmed.ncbi.nlm.nih.gov/24528043/

	Solvent	mg/mL	mM
Solubility
	DMSO	48.0	337.77
	Ethanol	5.0	35.18
	PBS (pH 7.2)	5.0	35.18
	Water	50.0	351.84

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 142.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Pereira JAL, Moraes LS, Sena CBC, Nascimento JLMD, Rodrigues APD, Silva SHMD, Silva EO. Inhibition of Melanization by Kojic Acid Promotes Cell Wall Disruption of the Human Pathogenic Fungus Fonsecaea sp. Pathogens. 2022 Aug 17;11(8):925. doi: 10.3390/pathogens11080925. PMID: 36015045; PMCID: PMC9414132. 2. Wei X, Luo D, Yan Y, Yu H, Sun L, Wang C, Song F, Ge H, Qian H, Li X, Tang X, Liu P. Kojic acid inhibits senescence of human corneal endothelial cells via NF-κB and p21 signaling pathways. Exp Eye Res. 2019 Mar;180:174-183. doi: 10.1016/j.exer.2018.12.020. Epub 2018 Dec 28. PMID: 30597146. 3. Wang K, Liu C, Di CJ, Ma C, Han CG, Yuan MR, Li PF, Li L, Liu YX. Kojic acid protects C57BL/6 mice from gamma-irradiation induced damage. Asian Pac J Cancer Prev. 2014;15(1):291-7. doi: 10.7314/apjcp.2014.15.1.291. PMID: 24528043. 4. Rodrigues AP, Farias LH, Carvalho AS, Santos AS, do Nascimento JL, Silva EO. A novel function for kojic acid, a secondary metabolite from Aspergillus fungi, as antileishmanial agent. PLoS One. 2014 Mar 12;9(3):e91259. doi: 10.1371/journal.pone.0091259. PMID: 24621481; PMCID: PMC3951352.

In vitro protocol:

In vivo protocol:

1. Wang K, Liu C, Di CJ, Ma C, Han CG, Yuan MR, Li PF, Li L, Liu YX. Kojic acid protects C57BL/6 mice from gamma-irradiation induced damage. Asian Pac J Cancer Prev. 2014;15(1):291-7. doi: 10.7314/apjcp.2014.15.1.291. PMID: 24528043. 2. Rodrigues AP, Farias LH, Carvalho AS, Santos AS, do Nascimento JL, Silva EO. A novel function for kojic acid, a secondary metabolite from Aspergillus fungi, as antileishmanial agent. PLoS One. 2014 Mar 12;9(3):e91259. doi: 10.1371/journal.pone.0091259. PMID: 24621481; PMCID: PMC3951352.

1: Perper M, Eber AE, Fayne R, Verne SH, Magno RJ, Cervantes J, ALharbi M, ALOmair I, Alfuraih A, Nouri K. Tranexamic Acid in the Treatment of Melasma: A Review of the Literature. Am J Clin Dermatol. 2017 Jun;18(3):373-381. doi: 10.1007/s40257-017-0263-3. Review. PubMed PMID: 28283893. 2: Nurchi VM, Crisponi G, Lachowicz JI, Medici S, Peana M, Zoroddu MA. Chemical features of in use and in progress chelators for iron overload. J Trace Elem Med Biol. 2016 Dec;38:10-18. doi: 10.1016/j.jtemb.2016.05.010. Epub 2016 Jun 9. Review. PubMed PMID: 27365273. 3: Gunia-Krzyżak A, Popiol J, Marona H. Melanogenesis Inhibitors: Strategies for Searching for and Evaluation of Active Compounds. Curr Med Chem. 2016;23(31):3548-3574. Review. PubMed PMID: 27356545. 4: Desmedt B, Courselle P, De Beer JO, Rogiers V, Grosber M, Deconinck E, De Paepe K. Overview of skin whitening agents with an insight into the illegal cosmetic market in Europe. J Eur Acad Dermatol Venereol. 2016 Jun;30(6):943-50. doi: 10.1111/jdv.13595. Epub 2016 Mar 8. Review. PubMed PMID: 26953335. 5: Shokeen D. Postinflammatory hyperpigmentation in patients with skin of color. Cutis. 2016 Jan;97(1):E9-E11. Review. PubMed PMID: 26919365. 6: Gallo A, Giuberti G, Frisvad JC, Bertuzzi T, Nielsen KF. Review on Mycotoxin Issues in Ruminants: Occurrence in Forages, Effects of Mycotoxin Ingestion on Health Status and Animal Performance and Practical Strategies to Counteract Their Negative Effects. Toxins (Basel). 2015 Aug 12;7(8):3057-111. doi: 10.3390/toxins7083057. Review. PubMed PMID: 26274974; PubMed Central PMCID: PMC4549740. 7: Maloney PR, Khan P, Hedrick M, Gosalia P, Milewski M, Li L, Roth GP, Sergienko E, Suyama E, Sugarman E, Nguyen K, Mehta A, Vasile S, Su Y, Stonich D, Nguyen H, Zeng FY, Novo AM, Vicchiarelli M, Diwan J, Chung TDY, Pinkerton AB, Smith LH. Functional antagonists of the Apelin (APJ) receptor. 2011 Mar 22 [updated 2013 Mar 7]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available from http://www.ncbi.nlm.nih.gov/books/NBK133430/ PubMed PMID: 23658961. 8: Ylijoki KE, Stryker JM. [5 + 2] cycloaddition reactions in organic and natural product synthesis. Chem Rev. 2013 Mar 13;113(3):2244-66. doi: 10.1021/cr300087g. Epub 2012 Nov 15. Review. PubMed PMID: 23153111. 9: Crisponi G, Dean A, Di Marco V, Lachowicz JI, Nurchi VM, Remelli M, Tapparo A. Different approaches to the study of chelating agents for iron and aluminium overload pathologies. Anal Bioanal Chem. 2013 Jan;405(2-3):585-601. doi: 10.1007/s00216-012-6468-7. Epub 2012 Oct 25. Review. PubMed PMID: 23096940. 10: Sarkar R, Chugh S, Garg VK. Newer and upcoming therapies for melasma. Indian J Dermatol Venereol Leprol. 2012 Jul-Aug;78(4):417-28. doi: 10.4103/0378-6323.98071. Review. PubMed PMID: 22772611. 11: Sheth VM, Pandya AG. Melasma: a comprehensive update: part II. J Am Acad Dermatol. 2011 Oct;65(4):699-714; quiz 715. doi: 10.1016/j.jaad.2011.06.001. Review. PubMed PMID: 21920242. 12: Khanna N, Rasool S. Facial melanoses: Indian perspective. Indian J Dermatol Venereol Leprol. 2011 Sep-Oct;77(5):552-63; quiz 564. doi: 10.4103/0378-6323.84046. Review. PubMed PMID: 21860153. 13: Leyden JJ, Shergill B, Micali G, Downie J, Wallo W. Natural options for the management of hyperpigmentation. J Eur Acad Dermatol Venereol. 2011 Oct;25(10):1140-5. doi: 10.1111/j.1468-3083.2011.04130.x. Epub 2011 May 31. Review. PubMed PMID: 21623927. 14: Callender VD, St Surin-Lord S, Davis EC, Maclin M. Postinflammatory hyperpigmentation: etiologic and therapeutic considerations. Am J Clin Dermatol. 2011 Apr 1;12(2):87-99. doi: 10.2165/11536930-000000000-00000. Review. PubMed PMID: 21348540. 15: Burnett CL, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Final report of the safety assessment of Kojic acid as used in cosmetics. Int J Toxicol. 2010 Nov-Dec;29(6 Suppl):244S-73. doi: 10.1177/1091581810385956. Review. PubMed PMID: 21164073. 16: Puizina-Ivić N, Mirić L, Carija A, Karlica D, Marasović D. Modern approach to topical treatment of aging skin. Coll Antropol. 2010 Sep;34(3):1145-53. Review. PubMed PMID: 20977120. 17: Grimes PE. Management of hyperpigmentation in darker racial ethnic groups. Semin Cutan Med Surg. 2009 Jun;28(2):77-85. doi: 10.1016/j.sder.2009.04.001. Review. PubMed PMID: 19608057. 18: Chang TS. An updated review of tyrosinase inhibitors. Int J Mol Sci. 2009 May 26;10(6):2440-75. doi: 10.3390/ijms10062440. Review. PubMed PMID: 19582213; PubMed Central PMCID: PMC2705500. 19: Zhu W, Gao J. The use of botanical extracts as topical skin-lightening agents for the improvement of skin pigmentation disorders. J Investig Dermatol Symp Proc. 2008 Apr;13(1):20-4. doi: 10.1038/jidsymp.2008.8. Review. PubMed PMID: 18369335. 20: Trucksess MW, Scott PM. Mycotoxins in botanicals and dried fruits: a review. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008 Feb;25(2):181-92. doi: 10.1080/02652030701567459. Review. PubMed PMID: 18286408.