OPC-167832 is a 3,4-dihydrocarostyril derivative and DprE1 inhibitor developed by Otsuka. OPC-167832 also targets DprE1 and shows bactericidal activity against replicating and intracellular Mtb bacilli. Otsuka has a long history of drug development with this compound class for various clinical indications. OPC-167832 displays especially good synergism in combination with delamanid. OPC-167832 is currently in a phase I clinical trial.
MedKoo Cat#: 555714
Name: OPC-167832
CAS#: 1883747-71-4
Chemical Formula: C21H20ClF3N2O4
Exact Mass: 456.1064
Molecular Weight: 456.85
Elemental Analysis: C, 55.21; H, 4.41; Cl, 7.76; F, 12.48; N, 6.13; O, 14.01
The following data is based on the product molecular weight 456.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
