Synonym
Org 30029; Org30029; Org-30029
IUPAC/Chemical Name
Benzo(b)thiophene-2-carboximidamide, N-hydroxy-5,6-dimethoxy-, monohydrochloride
InChi Key
DVWBMWJOYIFITF-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H12N2O3S.ClH/c1-15-7-3-6-4-10(11(12)13-14)17-9(6)5-8(7)16-2;/h3-5,14H,1-2H3,(H2,12,13);1H
SMILES Code
N=C(C1=CC2=CC(OC)=C(OC)C=C2S1)NO.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
288.75
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Watanabe A, Tomoike H, Endoh M. Ca2+ sensitizer Org-30029 reverses acidosis- and BDM-induced contractile depression in canine myocardium. Am J Physiol. 1996 Nov;271(5 Pt 2):H1829-39. doi: 10.1152/ajpheart.1996.271.5.H1829. PMID: 8945898.
2: Kawabata Y, Endoh M. Effects of the positive inotropic agent Org 30029 on developed force and aequorin light transients in intact canine ventricular myocardium. Circ Res. 1993 Mar;72(3):597-606. doi: 10.1161/01.res.72.3.597. PMID: 8431987.
3: Grandis DJ, MacGowan GA, Koretsky AP. Comparison of the effects of ORG 30029, dobutamine and high perfusate calcium on function and metabolism in rat heart. J Mol Cell Cardiol. 1998 Dec;30(12):2605-12. doi: 10.1006/jmcc.1998.0817. PMID: 9990532.
4: El-Metwally M, Shafiee-Nick R, Pyne NJ, Furman BL. The effect of selective phosphodiesterase inhibitors on plasma insulin concentrations and insulin secretion in vitro in the rat. Eur J Pharmacol. 1997 Apr 18;324(2-3):227-32. doi: 10.1016/s0014-2999(97)00076-9. PMID: 9145777.
5: Endoh M. Cardiac Ca2+ signaling and Ca2+ sensitizers. Circ J. 2008 Dec;72(12):1915-25. doi: 10.1253/circj.cj-08-0838. Epub 2008 Nov 4. PMID: 18981594.
6: Hajjar RJ, Schmidt U, Helm P, Gwathmey JK. Ca++ sensitizers impair cardiac relaxation in failing human myocardium. J Pharmacol Exp Ther. 1997 Jan;280(1):247-54. PMID: 8996203.
7: Nicholson CD, Cottney J, Marsden G, Shahid M. A comparison of the inotropic activity of Org 30029, IBMX, milrinone and rolipram in rat papillary muscles. Br J Pharmacol. 1989 Dec;98 Suppl:802P. PMID: 2482109.
8: de Boer J, Philpott AJ, van Amsterdam RG, Shahid M, Zaagsma J, Nicholson CD. Human bronchial cyclic nucleotide phosphodiesterase isoenzymes: biochemical and pharmacological analysis using selective inhibitors. Br J Pharmacol. 1992 Aug;106(4):1028-34. doi: 10.1111/j.1476-5381.1992.tb14451.x. PMID: 1393276; PMCID: PMC1907637.
9: Shahid M, Nicholson CD. Comparison of cyclic nucleotide phosphodiesterase isoenzymes in rat and rabbit ventricular myocardium: positive inotropic and phosphodiesterase inhibitory effects of Org 30029, milrinone and rolipram. Naunyn Schmiedebergs Arch Pharmacol. 1990 Dec;342(6):698-705. doi: 10.1007/BF00175715. PMID: 1710786.
10: Endoh M. The effects of various drugs on the myocardial inotropic response. Gen Pharmacol. 1995 Jan;26(1):1-31. doi: 10.1016/0306-3623(94)00144-c. PMID: 7713348.
