MedKoo Cat#: 555379 | Name: GSK2814338 free base
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK2814338, also known as Lp-PLA2 -IN-1, is a Lp-PLA2 inhibitor

Chemical Structure

GSK2814338 free base
GSK2814338 free base
CAS#1420367-28-7 (free base)

Theoretical Analysis

MedKoo Cat#: 555379

Name: GSK2814338 free base

CAS#: 1420367-28-7 (free base)

Chemical Formula: C21H17F5N4O3

Exact Mass: 468.1221

Molecular Weight: 468.38

Elemental Analysis: C, 53.85; H, 3.66; F, 20.28; N, 11.96; O, 10.25

Price and Availability

Size Price Availability Quantity
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
200mg USD 1,250.00 2 Weeks
500mg USD 2,650.00 2 Weeks
1g USD 3,950.00 2 Weeks
2g USD 6,450.00 2 Weeks
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Synonym
Lp-PLA2 -IN-1; Lp-PLA2-IN-1; GSK2814338; GSK-2814338; GSK 2814338;
IUPAC/Chemical Name
8-((3,5-difluoro-4-((6-(trifluoromethyl)pyridin-3-yl)oxy)benzyl)oxy)-1-methyl-1,2,3,4-tetrahydro-6H-pyrimido[1,6-a]pyrimidin-6-one
InChi Key
QJIGPJZJKXZSNF-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H17F5N4O3/c1-29-5-2-6-30-18(29)9-17(28-20(30)31)32-11-12-7-14(22)19(15(23)8-12)33-13-3-4-16(27-10-13)21(24,25)26/h3-4,7-10H,2,5-6,11H2,1H3
SMILES Code
CN1C(N2CCC1)=CC(OCC3=CC(F)=C(OC4=CC=C(C(F)(F)F)N=C4)C(F)=C3)=NC2=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Biological target:
Lp-PLA2-IN-1 is a potent Lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor.
In vitro activity:
TBD
In vivo activity:
TBD
Solvent mg/mL mM
Solubility
Ethanol 25.0 53.38
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 468.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
[1]. Zehong Wan, et al. Bicyclic pyrimidone compounds. WO2013014185A1. https://patents.google.com/patent/WO2013014185A1/en?oq=WO2013014185A1