SH-11037 | CAS#1638153-78-2 | seh inhibitor

MedKoo Cat#: 565756 | Name: SH-11037

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SH-11037 is a novel potent seh inhibitor, effectively blocking key angiogenic properties of human retinal endothelial cells (hrecs), inhibiting choroidal sprouting and significantly suppressing cnv lesion volume

Chemical Structure

SH-11037

CAS#1638153-78-2

Theoretical Analysis

MedKoo Cat#: 565756

Name: SH-11037

CAS#: 1638153-78-2

Chemical Formula: C34H39NO10

Exact Mass: 621.2574

Molecular Weight: 621.68

Elemental Analysis: C, 65.69; H, 6.32; N, 2.25; O, 25.73

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

1638153-78-2 2374821-51-7 (RS-isomer) 2374821-59-5 (SS-isomer) 2374821-53-9 (RR-isomer) 2374821-61-9 (SR-isomer) 2538360-89-1

Synonym

SH-11037; SH 11037; SH11037

IUPAC/Chemical Name

2-Methoxy-5-((5,6,7-trimethoxy-4-oxochroman-3-yl)methyl)phenyl (tert-butoxycarbonyl)-L-phenylalaninate

InChi Key

WNDLJGVBWVLFKK-WCSIJFPASA-N

InChi Code

InChI=1S/C34H39NO10/c1-34(2,3)45-33(38)35-23(16-20-11-9-8-10-12-20)32(37)44-25-17-21(13-14-24(25)39-4)15-22-19-43-26-18-27(40-5)30(41-6)31(42-7)28(26)29(22)36/h8-14,17-18,22-23H,15-16,19H2,1-7H3,(H,35,38)/t22?,23-/m0/s1

SMILES Code

O=C(OC1=CC(CC2COC3=C(C(OC)=C(OC)C(OC)=C3)C2=O)=CC=C1OC)[C@H](CC4=CC=CC=C4)NC(OC(C)(C)C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 621.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Sulaiman RS, Merrigan S, Quigley J, Qi X, Lee B, Boulton ME, Kennedy B, Seo SY, Corson TW. A novel small molecule ameliorates ocular neovascularisation and synergises with anti-VEGF therapy. Sci Rep. 2016 May 5;6:25509. doi: 10.1038/srep25509. PubMed PMID: 27148944; PubMed Central PMCID: PMC4857741. 2: Sulaiman RS, Park B, Sheik Pran Babu SP, Si Y, Kharwadkar R, Mitter SK, Lee B, Sun W, Qi X, Boulton ME, Meroueh SO, Fei X, Seo SY, Corson TW. Chemical Proteomics Reveals Soluble Epoxide Hydrolase as a Therapeutic Target for Ocular Neovascularization. ACS Chem Biol. 2018 Jan 19;13(1):45-52. doi: 10.1021/acschembio.7b00854. Epub 2017 Dec 1. PubMed PMID: 29193961; PubMed Central PMCID: PMC5775043. 3: Lee B, Sun W, Lee H, Basavarajappa H, Sulaiman RS, Sishtla K, Fei X, Corson TW, Seo SY. Design, synthesis and biological evaluation of photoaffinity probes of antiangiogenic homoisoflavonoids. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4277-81. doi: 10.1016/j.bmcl.2016.07.043. Epub 2016 Jul 21. PubMed PMID: 27481561; PubMed Central PMCID: PMC5129841.