MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 526635 | Name: Difloxacin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Difloxacin is a second-generation, broad-spectrum, concentration dependent antibiotic.

Chemical Structure

Difloxacin
CAS#98106-17-3 (free base)

Theoretical Analysis

MedKoo Cat#: 526635

Name: Difloxacin

CAS#: 98106-17-3 (free base)

Chemical Formula: C21H19F2N3O3

Exact Mass: 399.1394

Molecular Weight: 399.40

Elemental Analysis: C, 63.15; H, 4.80; F, 9.51; N, 10.52; O, 12.02

Price and Availability

Size Price Availability Quantity
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
98106-17-3 (free base) 91296-86-5 (HCl)
Synonym
Difloxacin; Dicural; Difloxacine; Pulsaflox;
IUPAC/Chemical Name
6-Fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
InChi Key
NOCJXYPHIIZEHN-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H19F2N3O3/c1-24-6-8-25(9-7-24)19-11-18-15(10-17(19)23)20(27)16(21(28)29)12-26(18)14-4-2-13(22)3-5-14/h2-5,10-12H,6-9H2,1H3,(H,28,29)
SMILES Code
O=C(C1=CN(C2=CC=C(F)C=C2)C3=C(C=C(F)C(N4CCN(C)CC4)=C3)C1=O)O
Appearance
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 399.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kreizinger Z, Grózner D, Sulyok KM, Nilsson K, Hrivnák V, Benčina D, Gyuranecz M. Antibiotic susceptibility profiles of Mycoplasma synoviae strains originating from Central and Eastern Europe. BMC Vet Res. 2017 Nov 17;13(1):342. doi: 10.1186/s12917-017-1266-2. PubMed PMID: 29149886; PubMed Central PMCID: PMC5693497. 2: Liang S, Lu L, Meng F. DOM-mediated membrane retention of fluoroquinolone as revealed by fluorescence quenching properties. Sci Rep. 2017 Jul 14;7(1):5372. doi: 10.1038/s41598-017-05635-z. PubMed PMID: 28710360; PubMed Central PMCID: PMC5511141. 3: Rusch M, Spielmeyer A, Meißner J, Kietzmann M, Zorn H, Hamscher G. Efficient Reduction of Antibacterial Activity and Cytotoxicity of Fluoroquinolones by Fungal-Mediated N-Oxidation. J Agric Food Chem. 2017 Apr 19;65(15):3118-3126. doi: 10.1021/acs.jafc.7b01246. Epub 2017 Apr 10. PubMed PMID: 28365994. 4: Serrano-Rodríguez JM, Cárceles-García C, Cárceles-Rodríguez CM, Gabarda ML, Serrano-Caballero JM, Fernández-Varón E. Susceptibility and PK/PD relationships of Staphylococcus aureus strains from ovine and caprine with clinical mastitis against five veterinary fluoroquinolones. Vet Rec. 2017 Apr 15;180(15):376. doi: 10.1136/vr.103964. Epub 2017 Feb 17. PubMed PMID: 28213532. 5: Teglia CM, Cámara MS, Vera-Candioti L. Dispersive liquid-liquid microextraction of quinolones in porcine blood: Validation of a CE method using univariate calibration or multivariate curve resolution-alternating least squares for overlapped peaks. Electrophoresis. 2017 Apr;38(8):1122-1129. doi: 10.1002/elps.201600475. Epub 2017 Mar 6. PubMed PMID: 28177131. 6: Lee SJ, Awji EG, Park NH, Park SC. Using In Vitro Dynamic Models To Evaluate Fluoroquinolone Activity against Emergence of Resistant Salmonella enterica Serovar Typhimurium. Antimicrob Agents Chemother. 2017 Jan 24;61(2). pii: e01756-16. doi: 10.1128/AAC.01756-16. Print 2017 Feb. PubMed PMID: 27895011; PubMed Central PMCID: PMC5278752. 7: Grózner D, Kreizinger Z, Sulyok KM, Rónai Z, Hrivnák V, Turcsányi I, Jánosi S, Gyuranecz M. Antibiotic susceptibility profiles of Mycoplasma sp. 1220 strains isolated from geese in Hungary. BMC Vet Res. 2016 Aug 19;12(1):170. doi: 10.1186/s12917-016-0799-0. PubMed PMID: 27543140; PubMed Central PMCID: PMC4992293. 8: da Silva MC, Orlando RM, Faria AF. Electrical field assisted matrix solid phase dispersion as a powerful tool to improve the extraction efficiency and clean-up of fluoroquinolones in bovine milk. J Chromatogr A. 2016 Aug 26;1461:27-34. doi: 10.1016/j.chroma.2016.07.063. Epub 2016 Jul 25. PubMed PMID: 27492598. 9: Snowberger S, Adejumo H, He K, Mangalgiri KP, Hopanna M, Soares AD, Blaney L. Direct Photolysis of Fluoroquinolone Antibiotics at 253.7 nm: Specific Reaction Kinetics and Formation of Equally Potent Fluoroquinolone Antibiotics. Environ Sci Technol. 2016 Sep 6;50(17):9533-42. doi: 10.1021/acs.est.6b01794. Epub 2016 Aug 17. PubMed PMID: 27479003. 10: Chen M, Wen F, Wang H, Zheng N, Wang J. Effect of various storage conditions on the stability of quinolones in raw milk. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2016 Jul;33(7):1147-54. doi: 10.1080/19440049.2016.1184051. Epub 2016 Jun 9. PubMed PMID: 27258809. 11: Gaudin V, Hedou C, Soumet C, Verdon E. Evaluation and validation of a multi-residue method based on biochip technology for the simultaneous screening of six families of antibiotics in muscle and aquaculture products. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2016;33(3):403-19. doi: 10.1080/19440049.2015.1125529. Epub 2016 Jan 25. PubMed PMID: 26612266. 12: Jin T, Wu H, Gao N, Chen X, Lai H, Zheng J, Du L. Extraction of quinolones from milk samples using bentonite/magnetite nanoparticles before determination by high-performance liquid chromatography with fluorimetric detection. J Sep Sci. 2016 Feb;39(3):545-51. doi: 10.1002/jssc.201500856. Epub 2015 Dec 15. PubMed PMID: 26576704. 13: Pereira AM, Silva LJ, Meisel LM, Pena A. Fluoroquinolones and Tetracycline Antibiotics in a Portuguese Aquaculture System and Aquatic Surroundings: Occurrence and Environmental Impact. J Toxicol Environ Health A. 2015;78(15):959-75. doi: 10.1080/15287394.2015.1036185. PubMed PMID: 26262440. 14: Kim NG, Kim MA, Park YI, Jung TS, Son SW, So B, Kang HG. Magnetic nanoparticle based purification and enzyme-linked immunosorbent assay using monoclonal antibody against enrofloxacin. J Vet Sci. 2015;16(4):431-7. doi: 10.4142/jvs.2015.16.4.431. PubMed PMID: 26040610; PubMed Central PMCID: PMC4701735. 15: Ge L, Na G, Zhang S, Li K, Zhang P, Ren H, Yao Z. New insights into the aquatic photochemistry of fluoroquinolone antibiotics: Direct photodegradation, hydroxyl-radical oxidation, and antibacterial activity changes. Sci Total Environ. 2015 Sep 15;527-528:12-7. doi: 10.1016/j.scitotenv.2015.04.099. Epub 2015 May 14. PubMed PMID: 25956144. 16: Gorissen B, Reyns T, Devreese M, De Backer P, Van Loco J, Croubels S. Determination of selected veterinary antimicrobials in poultry excreta by UHPLC-MS/MS, for application in Salmonella control programs. Anal Bioanal Chem. 2015 Jun;407(15):4447-57. doi: 10.1007/s00216-014-8449-5. Epub 2015 Jan 30. PubMed PMID: 25633214. 17: Rocha DG, Santos FA, da Silva JC, Augusti R, Faria AF. Multiresidue determination of fluoroquinolones in poultry muscle and kidney according to the regulation 2002/657/EC. A systematic comparison of two different approaches: Liquid chromatography coupled to high-resolution mass spectrometry or tandem mass spectrometry. J Chromatogr A. 2015 Jan 30;1379:83-91. doi: 10.1016/j.chroma.2014.12.058. Epub 2014 Dec 29. PubMed PMID: 25577647. 18: Talebiyan R, Kheradmand M, Khamesipour F, Rabiee-Faradonbeh M. Multiple Antimicrobial Resistance of Escherichia coli Isolated from Chickens in Iran. Vet Med Int. 2014;2014:491418. doi: 10.1155/2014/491418. Epub 2014 Dec 7. PubMed PMID: 25548716; PubMed Central PMCID: PMC4273530. 19: He K, Soares AD, Adejumo H, McDiarmid M, Squibb K, Blaney L. Detection of a wide variety of human and veterinary fluoroquinolone antibiotics in municipal wastewater and wastewater-impacted surface water. J Pharm Biomed Anal. 2015 Mar 15;106:136-43. doi: 10.1016/j.jpba.2014.11.020. Epub 2014 Nov 18. PubMed PMID: 25483174. 20: Cheng G, Dong X, Wang Y, Peng D, Wang X, Hao H, Xie S, Qu W, Liu Z, Yuan Z. Development of a novel genetically modified bioluminescent-bacteria-based assay for detection of fluoroquinolones in animal-derived foods. Anal Bioanal Chem. 2014 Dec;406(30):7899-910. doi: 10.1007/s00216-014-8228-3. Epub 2014 Oct 30. PubMed PMID: 25354889.