Difloxacin HCl | CAS#91296-86-5 | bacterial DNA gyrase inhibitor

MedKoo Cat#: 540108 | Name: Difloxacin HCl

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Difloxacin HCl is a bacterial DNA gyrase inhibitor. It suppresses growth of Staphylococus, Escherichia and Pasturella.

Chemical Structure

Difloxacin HCl

CAS#91296-86-5 (HCl)

Theoretical Analysis

MedKoo Cat#: 540108

Name: Difloxacin HCl

CAS#: 91296-86-5 (HCl)

Chemical Formula: C21H20ClF2N3O3

Exact Mass: 435.1161

Molecular Weight: 435.85

Elemental Analysis: C, 57.87; H, 4.63; Cl, 8.13; F, 8.72; N, 9.64; O, 11.01

Price and Availability

Size	Price	Availability
1g	USD 250.00	2 Weeks
5g	USD 650.00	2 Weeks
10g	USD 950.00	2 Weeks

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Related CAS #

98106-17-3 (free base) 91296-86-5 (HCl)

Synonym

A-56619; A56619; A 56619; Difloxacin HCl; Vetranal; Difluoxacin hydrochloride; Difloxacin Hydrochloride Salt

IUPAC/Chemical Name

6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride

InChi Key

JFMGBGLSDVIOHL-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H19F2N3O3.ClH/c1-24-6-8-25(9-7-24)19-11-18-15(10-17(19)23)20(27)16(21(28)29)12-26(18)14-4-2-13(22)3-5-14;/h2-5,10-12H,6-9H2,1H3,(H,28,29);1H

SMILES Code

O=C(C1=CN(C2=CC=C(F)C=C2)C3=C(C=C(F)C(N4CCN(C)CC4)=C3)C1=O)O.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 435.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Structural and functional response of the soil bacterial community to application of manure from difloxacin-treated pigs. FEMS Microbiol Ecol. 2014 Jan;87(1):78-88. doi: 10.1111/1574-6941.12191. Epub 2013 Sep 16. PubMed PMID: 23962048. 5: Escudero E, Marín P, Cárceles CM, Ramírez MJ, Fernández-Varón E. Pharmacokinetic and milk penetration of a difloxacin long-acting poloxamer gel formulation with carboxy-methylcellulose in lactating goats. Vet J. 2011 Apr;188(1):92-5. doi: 10.1016/j.tvjl.2010.03.008. Epub 2010 Mar 31. PubMed PMID: 20359917. 6: Rosendahl I, Siemens J, Kindler R, Groeneweg J, Zimmermann J, Czerwinski S, Lamshöft M, Laabs V, Wilke BM, Vereecken H, Amelung W. Persistence of the fluoroquinolone antibiotic difloxacin in soil and lacking effects on nitrogen turnover. J Environ Qual. 2012 Jul-Aug;41(4):1275-83. doi: 10.2134/jeq2011.0459. PubMed PMID: 22751072. 7: Digranes A, Dibb WL. In vitro activities of A-56619 (difloxacin) and A-56620, two aryl fluoroquinolones. Chemotherapy. 1988;34(4):298-307. PubMed PMID: 3208547. 8: Marín P, Escudero E, Fernández-Varón E, Ramírez MJ, Cárceles CM. Pharmacokinetics and milk penetration of difloxacin after a long-acting formulation for subcutaneous administration to lactating goats. J Dairy Sci. 2010 Jul;93(7):3056-64. doi: 10.3168/jds.2010-3257. PubMed PMID: 20630222. 9: van den Hoven R, Wagenaar JA, Walker RD. In vitro activity of difloxacin against canine bacterial isolates. J Vet Diagn Invest. 2000 May;12(3):218-23. PubMed PMID: 10826834. 10: Fernández-Varón E, Cárceles CM, Marín P, Martos N, Escudero E, Ayala I. Pharmacokinetics of difloxacin after intravenous, intramuscular, and intragastric administration to horses. Am J Vet Res. 2006 Jun;67(6):1076-81. PubMed PMID: 16740105. 11: Abo-El-Sooud K, Goudah A. Pharmacokinetics and intramuscular bioavailability of difloxacin in dromedary camels (Camelus dromedarius). Vet J. 2009 Feb;179(2):282-6. doi: 10.1016/j.tvjl.2008.05.011. Epub 2008 Jul 7. PubMed PMID: 18603456. 12: Hubicka U, Zmudzki P, Zuromska-Witek B, Zajdel P, Pawłowski M, Krzek J. Separation and characterization of ciprofloxacin, difloxacin, lomefloxacin, norfloxacin, and ofloxacin oxidation products under potassium permanganate treatment in acidic medium by UPLC-MS/MS. Talanta. 2013 May 15;109:91-100. doi: 10.1016/j.talanta.2013.01.055. Epub 2013 Feb 5. PubMed PMID: 23618144. 13: Atef M, el-Banna HA, Abd El-Aty AM, Goudah A. Pharmacokinetics of difloxacin in goats. Dtsch Tierarztl Wochenschr. 2002 Jul;109(7):320-3. PubMed PMID: 12161971. 14: Guo J, Ostermann A, Siemens J, Dong R, Clemens J. Short term effects of copper, sulfadiazine and difloxacin on the anaerobic digestion of pig manure at low organic loading rates. Waste Manag. 2012 Jan;32(1):131-6. doi: 10.1016/j.wasman.2011.07.031. Epub 2011 Aug 24. PubMed PMID: 21868210. 15: Rao RN, Nagaraju V. Separation and determination of synthetic impurities of difloxacin by reversed-phase high-performance liquid chromatography. J Pharm Biomed Anal. 2004 Nov 19;36(4):729-35. PubMed PMID: 15533664. 16: Marín P, Fernández-Varón E, Escudero E, Cárceles CM. Pharmacokinetics after intravenous, intramuscular and subcutaneous administration of difloxacin in sheep. Res Vet Sci. 2007 Oct;83(2):234-8. Epub 2007 Mar 6. PubMed PMID: 17343888. 17: Olchowy TW, TerHune TN, Herrick RL. Efficacy of difloxacin in calves experimentally infected with Mannheimia haemolytica. Am J Vet Res. 2000 Jun;61(6):710-3. PubMed PMID: 10850850. 18: Fernández-varón E, Cárceles CM, Marín P, Vancraeynest D, Montes A, Sotillo J, García-Martínez JD. Disposition kinetics and pharmacokinetics--pharmacodynamic integration of difloxacin against Staphylococcus aureus isolates from rabbits. Res Vet Sci. 2008 Feb;84(1):90-4. Epub 2007 Jun 15. PubMed PMID: 17573085. 19: Marín P, Escudero E, Fernández-Varón E, Cárceles CM. Pharmacokinetics and milk penetration of difloxacin after intravenous, subcutaneous and intramuscular administration to lactating goats. J Vet Pharmacol Ther. 2007 Feb;30(1):74-9. PubMed PMID: 17217405. 20: Heinen E. Comparative serum pharmacokinetics of the fluoroquinolones enrofloxacin, difloxacin, marbofloxacin, and orbifloxacin in dogs after single oral administration. J Vet Pharmacol Ther. 2002 Feb;25(1):1-5. PubMed PMID: 11874520.