DIF-1 | CAS#111050-72-7

MedKoo Cat#: 533449 | Name: DIF-1

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

DIF-1 is an enhancer of NDRG1 expression for anti-GBM therapeutics, regulating between NDRG1and GSK3β to control tumor growth.

Chemical Structure

DIF-1

CAS#111050-72-7

Theoretical Analysis

MedKoo Cat#: 533449

Name: DIF-1

CAS#: 111050-72-7

Chemical Formula: C13H16Cl2O4

Exact Mass: 306.0426

Molecular Weight: 307.17

Elemental Analysis: C, 50.83; H, 5.25; Cl, 23.08; O, 20.83

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 500.00	2 Weeks
25mg	USD 950.00	2 Weeks

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Related CAS #

No Data

Synonym

DIF-1; DIF 1; DIF1

IUPAC/Chemical Name

1-((3,5-Dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone

InChi Key

VUDQSRFCCHQIIU-UHFFFAOYSA-N

InChi Code

InChI=1S/C13H16Cl2O4/c1-3-4-5-6-7(16)8-11(17)9(14)13(19-2)10(15)12(8)18/h17-18H,3-6H2,1-2H3

SMILES Code

CCCCCC(C1=C(O)C(Cl)=C(OC)C(Cl)=C1O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 307.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Juntendo Iji Zasshi. 2024 Sep 11;70(5):339-347. doi: 10.14789/jmj.JMJ24-0021-R. PMID: 39545231; PMCID: PMC11560335. 5: Tang T, Li J, Zhang B, Wen L, Lu Y, Hu Q, Yu XQ, Zhang J. Loss of function in Drosophila transcription factor Dif delays brain development in larvae resulting in aging adult brain. Int J Biol Macromol. 2024 Nov;281(Pt 3):136491. doi: 10.1016/j.ijbiomac.2024.136491. Epub 2024 Oct 10. PMID: 39393722. 6: Arioka M, Miura K, Han R, Igawa K, Takahashi-Yanaga F, Sasaguri T. Mammalian target of differentiation-inducing factor-1 is mitochondrial malate dehydrogenase for activation of AMP-activated protein kinase and induction of mitochondrial fission. Life Sci. 2024 Aug 15;351:122807. doi: 10.1016/j.lfs.2024.122807. Epub 2024 Jun 7. PMID: 38852800. 7: Yoshida N, Kikuchi H, Hirai M, Balikagala B, Anywar DA, Taka H, Kaga N, Miura Y, Fukuda N, Odongo-Aginya EI, Kubohara Y, Mita T. A longer-chain acylated derivative of Dictyostelium differentiation-inducing factor-1 enhances the antimalarial activity against Plasmodium parasites. Biochem Pharmacol. 2024 Jul;225:116243. doi: 10.1016/j.bcp.2024.116243. Epub 2024 Apr 30. PMID: 38697310. 8: Araya R, Men S, Uekusa Y, Yu Z, Kikuchi H, Daitoku K, Minakawa M, Kawaguchi S, Furukawa KI, Oshima Y, Imaizumi T, Seya K. The inhibitory effect of DIF-3 on polyinosinic-polycytidylic acid-induced innate immunity activation in human cerebral microvascular endothelial cells. J Pharmacol Sci. 2024 Mar;154(3):157-165. doi: 10.1016/j.jphs.2024.01.005. Epub 2024 Jan 17. PMID: 38395516. 9: Kubohara Y, Fukunaga Y, Shigenaga A, Kikuchi H. Dictyostelium Differentiation-Inducing Factor 1 Promotes Glucose Uptake via Direct Inhibition of Mitochondrial Malate Dehydrogenase in Mouse 3T3-L1 Cells. Int J Mol Sci. 2024 Feb 4;25(3):1889. doi: 10.3390/ijms25031889. PMID: 38339168; PMCID: PMC10855897. 10: Sorokin MY, Lutova NB, Bocharova MO, Khobeysh MA, Wied VD. Computational psychiatry approach to stigma subtyping in patients with mental disorders: explicit and implicit internalized stigma. Consort Psychiatr. 2023 Sep 29;4(3):13-21. doi: 10.17816/CP6556. PMID: 38249531; PMCID: PMC10795946. 11: Kubohara Y, Fukunaga Y, Kikuchi H, Kuwayama H. Pharmacological Evidence That Dictyostelium Differentiation-Inducing Factor 1 Promotes Glucose Uptake Partly via an Increase in Intracellular cAMP Content in Mouse 3T3-L1 Cells. Molecules. 2023 Dec 4;28(23):7926. doi: 10.3390/molecules28237926. PMID: 38067655; PMCID: PMC10708055. 12: Arioka M, Seto-Tetsuo F, Inoue T, Miura K, Ishikane S, Igawa K, Tomooka K, Takahashi-Yanaga F, Sasaguri T. Differentiation-inducing factor-1 reduces lipopolysaccharide-induced vascular cell adhesion molecule-1 by suppressing mTORC1-S6K signaling in vascular endothelial cells. Life Sci. 2023 Dec 15;335:122278. doi: 10.1016/j.lfs.2023.122278. Epub 2023 Nov 18. PMID: 37981227. 13: Kawabe Y, Du Q, Narita TB, Bell C, Schilde C, Kin K, Schaap P. Emerging roles for diguanylate cyclase during the evolution of soma in dictyostelia. BMC Ecol Evol. 2023 Oct 6;23(1):60. doi: 10.1186/s12862-023-02169-z. PMID: 37803310; PMCID: PMC10559540. 14: Kuwayama H, Kikuchi H, Kubohara Y. Derivatives of Differentiation-Inducing Factor 1 Differentially Control Chemotaxis and Stalk Cell Differentiation in Dictyostelium discoideum. Biology (Basel). 2023 Jun 16;12(6):873. doi: 10.3390/biology12060873. PMID: 37372157; PMCID: PMC10295651. 15: Hikage F, Watanabe M, Sato T, Umetsu A, Tsugeno Y, Furuhashi M, Ohguro H. Simultaneous Effects of a Selective EP2 Agonist, Omidenepag, and a Rho- Associated Coiled-Coil Containing Protein Kinase Inhibitor, Ripasudil, on Human Orbital Fibroblasts. J Ocul Pharmacol Ther. 2023 Sep;39(7):439-448. doi: 10.1089/jop.2023.0025. Epub 2023 Jun 23. PMID: 37352418. 16: Inoue T, Miura K, Han R, Seto-Tetsuo F, Arioka M, Igawa K, Tomooka K, Sasaguri T. Differentiation-inducing factor 1 activates cofilin through pyridoxal phosphatase and AMP-activated protein kinase, resulting in mitochondrial fission. J Pharmacol Sci. 2023 May;152(1):39-49. doi: 10.1016/j.jphs.2023.02.009. Epub 2023 Mar 14. PMID: 37059490. 17: Hirayama A, Ishigaki H, Takahashi K, Miura Y, Kikuchi H, Kubohara Y. Dictyostelium Differentiation-inducing Factor Derivatives Reduce the Glycosylation of PD-L1 in MDA-MB-231 Human Breast Cancer Cells. Juntendo Iji Zasshi. 2023 Mar 13;69(2):105-115. doi: 10.14789/jmj.JMJ22-0039-OA. PMID: 38854456; PMCID: PMC11153063. 18: Seto-Tetsuo F, Arioka M, Miura K, Inoue T, Igawa K, Tomooka K, Sasaguri T. DIF-1 exhibits anticancer activity in breast cancer via inhibition of CXCLs/CXCR2 axis-mediated communication between cancer-associated fibroblasts and cancer cells. Int Immunopharmacol. 2023 Apr;117:109913. doi: 10.1016/j.intimp.2023.109913. Epub 2023 Feb 20. PMID: 36812674. 19: Saito T, Iijima T, Koyama K, Shinagawa T, Yamanaka A, Araki T, Suzuki N, Usuki T, Kay RR. Generating polyketide diversity in Dictyostelium: a Steely hybrid polyketide synthase produces alternate products at different developmental stages. Proc Biol Sci. 2022 Sep 28;289(1983):20221176. doi: 10.1098/rspb.2022.1176. Epub 2022 Sep 21. PMID: 36126683; PMCID: PMC9489281. 20: Forbes G, Chen ZH, Kin K, Schaap P. Novel RNAseq-Informed Cell-type Markers and Their Regulation Alter Paradigms of Dictyostelium Developmental Control. Front Cell Dev Biol. 2022 May 5;10:899316. doi: 10.3389/fcell.2022.899316. PMID: 35602609; PMCID: PMC9117722.