MedKoo Cat#: 565227 | Name: TED-347
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TED-347 is a covalent inhibitor of TEAD4-Yap1 protein-protein interaction in mammalian cells which blocks iTEAD transcriptional activity and inhibits glioblastoma cell viability.

Chemical Structure

TED-347
TED-347
CAS#2378626-29-8 (free base)

Theoretical Analysis

MedKoo Cat#: 565227

Name: TED-347

CAS#: 2378626-29-8 (free base)

Chemical Formula: C15H11ClF3NO

Exact Mass: 313.0481

Molecular Weight: 313.70

Elemental Analysis: C, 57.43; H, 3.53; Cl, 11.30; F, 18.17; N, 4.47; O, 5.10

Price and Availability

Size Price Availability Quantity
25mg USD 350.00 2 Weeks
50mg USD 550.00 2 Weeks
100mg USD 950.00 2 Weeks
1g USD 4,250.00 2 Weeks
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Synonym
TED347; TED 347; TED-347
IUPAC/Chemical Name
2-Chloro-1-(2-((3-(trifluoromethyl)phenyl)amino)phenyl)ethan-1-one
InChi Key
JPVDFGYNLUBCSD-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H11ClF3NO/c16-9-14(21)12-6-1-2-7-13(12)20-11-5-3-4-10(8-11)15(17,18)19/h1-8,20H,9H2
SMILES Code
O=C(C1=CC=CC=C1NC2=CC=CC(C(F)(F)F)=C2)CCl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Certificate of Analysis
Safety Data Sheet (SDS)

Preparing Stock Solutions

The following data is based on the product molecular weight 313.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Zhou H, Tan L, Zhang B, Kwong DLW, Wong CN, Zhang Y, Ru B, Lyu Y, Siu KTH, Luo J, Yang Y, Liu Q, Chen Y, Zhang W, He C, Jiang P, Qin Y, Liu B, Guan XY. GPRC5A promotes lung colonization of esophageal squamous cell carcinoma. Nat Commun. 2024 Nov 16;15(1):9950. doi: 10.1038/s41467-024-54251-9. PMID: 39550386; PMCID: PMC11569164.