Tegobuvir | GS-9190 | GS-333126 | CAS#1000787-75-6 | Polymerase inhibitor

MedKoo Cat#: 319800 | Name: Tegobuvir

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tegobuvir, also known as GS-9190 and GS-333126, is a potent non-nucleoside polymerase inhibitor. Tegobuvir (GS-9190) had EC(50)s of <16 nM against genotype 1 and >100 nM for other genotypes tested. Tegobuvir is highly efficient in curing cells from HCV replicon and in delaying/preventing the development of drug resistance. GS-9190 represents a novel class of nonnucleoside polymerase inhibitors that interact with NS5B likely through involvement of the β-hairpin in the thumb subdomain.

Chemical Structure

Tegobuvir

CAS#1000787-75-6

Theoretical Analysis

MedKoo Cat#: 319800

Name: Tegobuvir

CAS#: 1000787-75-6

Chemical Formula: C25H14F7N5

Exact Mass: 517.1137

Molecular Weight: 517.41

Elemental Analysis: C, 58.03; H, 2.73; F, 25.70; N, 13.54

Price and Availability

Size	Price	Availability
10mg	USD 250.00	2 Weeks
25mg	USD 450.00	2 Weeks
100mg	USD 1,250.00	2 Weeks
1g	USD 4,250.00	2 Weeks
2g	USD 6,850.00	2 Weeks

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Related CAS #

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Synonym

GS-9190; GS 9190; GS9190; GS-333126; GS 333126; GS333126; Tegobuvir

IUPAC/Chemical Name

5-((6-(2,4-bis(trifluoromethyl)phenyl)pyridazin-3-yl)methyl)-2-(2-fluorophenyl)-5H-imidazo[4,5-c]pyridine

InChi Key

XBEQSQDCBSKCHJ-UHFFFAOYSA-N

InChi Code

InChI=1S/C25H14F7N5/c26-19-4-2-1-3-17(19)23-33-21-9-10-37(13-22(21)34-23)12-15-6-8-20(36-35-15)16-7-5-14(24(27,28)29)11-18(16)25(30,31)32/h1-11,13H,12H2

SMILES Code

FC1=CC=CC=C1C2=NC3=CN(CC4=NN=C(C5=CC=C(C(F)(F)F)C=C5C(F)(F)F)C=C4)C=CC3=N2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 517.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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