GSK-A1 | CAS#1416334-69-4

MedKoo Cat#: 427469 | Name: GSK-A1

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK-A1 is a novel potent inhibitor of PI4KA.

Chemical Structure

GSK-A1

CAS#1416334-69-4

Theoretical Analysis

MedKoo Cat#: 427469

Name: GSK-A1

CAS#: 1416334-69-4

Chemical Formula: C29H27FN6O4S

Exact Mass: 574.1799

Molecular Weight: 574.63

Elemental Analysis: C, 60.62; H, 4.74; F, 3.31; N, 14.63; O, 11.14; S, 5.58

Price and Availability

Size	Price	Availability
5mg	USD 350.00	2 Weeks
10mg	USD 650.00	2 Weeks
25mg	USD 1,250.00	2 Weeks

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Synonym

GSK-A1; GSK A1; GSKA1; PI4KA inhibitor-A1;

IUPAC/Chemical Name

5-[2-Amino-3-(4-morpholin-4-ylphenyl)benzimidazol-5-yl]-N-(2-fluorophenyl)-2-methoxypyridine-3-sulfonamide

InChi Key

AJOGHKUZDLYXKS-UHFFFAOYSA-N

InChi Code

InChI=1S/C29H27FN6O4S/c1-39-28-27(41(37,38)34-24-5-3-2-4-23(24)30)17-20(18-32-28)19-6-11-25-26(16-19)36(29(31)33-25)22-9-7-21(8-10-22)35-12-14-40-15-13-35/h2-11,16-18,34H,12-15H2,1H3,(H2,31,33)

SMILES Code

O=S(C1=CC(C2=CC=C3C(N(C4=CC=C(N5CCOCC5)C=C4)C(N)=N3)=C2)=CN=C1OC)(NC6=CC=CC=C6F)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 574.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Beebe SJ, Reimann EM, Schlender KK. Purification and characterization of a cAMP- and Ca2+-calmodulin-independent glycogen synthase kinase from porcine renal cortex. J Biol Chem. 1984 Feb 10;259(3):1415-22. PubMed PMID: 6319398.