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MedKoo Cat#: 408071 | Name: TED-347 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TED-347 is a Novel covalent inhibitor of TEAD4-Yap1 protein-protein interaction in mammalian cells, blocking iTEAD transcriptional activity and inhibiting glioblastoma cell viability.

Chemical Structure

TED-347 HCl
TED-347 HCl
CAS#TED-347 HCl

Theoretical Analysis

MedKoo Cat#: 408071

Name: TED-347 HCl

CAS#: TED-347 HCl

Chemical Formula: C15H12Cl2F3NO

Exact Mass: 313.0481

Molecular Weight: 350.16

Elemental Analysis: C, 51.45; H, 3.45; Cl, 20.25; F, 16.28; N, 4.00; O, 4.57

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
2378626-29-8 (free base) TED-347 HCl
Synonym
TED-347; TED 347; TED347; TED-347 HCl
IUPAC/Chemical Name
2-Chloro-1-(2-((3-(trifluoromethyl)phenyl)amino)phenyl)ethan-1-one hydrochloride
InChi Key
PIBMQTDKMKPAKH-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H11ClF3NO.ClH/c16-9-14(21)12-6-1-2-7-13(12)20-11-5-3-4-10(8-11)15(17,18)19;/h1-8,20H,9H2;1H
SMILES Code
O=C(C1=CC=CC=C1NC2=CC=CC(C(F)(F)F)=C2)CCl.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 350.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Zhou H, Tan L, Zhang B, Kwong DLW, Wong CN, Zhang Y, Ru B, Lyu Y, Siu KTH, Luo J, Yang Y, Liu Q, Chen Y, Zhang W, He C, Jiang P, Qin Y, Liu B, Guan XY. GPRC5A promotes lung colonization of esophageal squamous cell carcinoma. Nat Commun. 2024 Nov 16;15(1):9950. doi: 10.1038/s41467-024-54251-9. PMID: 39550386; PMCID: PMC11569164.