|
Solvent |
mg/mL |
mM |
| Solubility |
| DMF |
20.0 |
44.36 |
| DMSO |
20.0 |
44.36 |
| Ethanol |
5.0 |
11.09 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
450.87
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Yang X, Zhao L, Almasy L, Garamus VM, Zou A, Willumeit R, Fan S. Preparation and characterization of 4-dedimethylamino sancycline (CMT-3) loaded nanostructured lipid carrier (CMT-3/NLC) formulations. Int J Pharm. 2013 Jun 25;450(1-2):225-34. doi: 10.1016/j.ijpharm.2013.04.021. Epub 2013 Apr 20. PubMed PMID: 23608200.
2: Pinsuwan S, Alvarez-Núñez FA, Tabibi SE, Yalkowsky SH. Spectrophotometric determination of acidity constants of 4-dedimethylamino sancycline (Col-3), a new antitumor drug. J Pharm Sci. 1999 May;88(5):535-7. PubMed PMID: 10229645.
3: Hasan T, Goldman RA, Cooperman BS. Photoaffinity labeling of the tetracycline binding site of the Escherichia coli ribosome. The uses of a high intensity light source and of radioactive sancycline derivatives. Biochem Pharmacol. 1985 Apr 1;34(7):1065-71. PubMed PMID: 3885955.
4: Pinsuwan S, Alvarez-Núñez FA, Tabibi ES, Yalkowsky SH. Degradation kinetics of 4-dedimethylamino sancycline, a new anti-tumor agent, in aqueous solutions. Int J Pharm. 1999 Apr 20;181(1):31-40. PubMed PMID: 10370200.
5: García-Ruiz C, Crego AL, Lavandera JL, Marina ML. Rapid separation of tetracycline derivatives and their main degradation products by capillary zone electrophoresis. Electrophoresis. 2001 Aug;22(13):2775-81. PubMed PMID: 11545407.
6: Nelson ML, Ismail MY, McIntyre L, Bhatia B, Viski P, Hawkins P, Rennie G, Andorsky D, Messersmith D, Stapleton K, Dumornay J, Sheahan P, Verma AK, Warchol T, Levy SB. Versatile and facile synthesis of diverse semisynthetic tetracycline derivatives via Pd-catalyzed reactions. J Org Chem. 2003 Jul 25;68(15):5838-51. Erratum in: J Org Chem. 2003 Dec 26;68(26):10199. PubMed PMID: 12868916.
7: MUXFELDT H, ROGALSKI W. TETRACYCLINES. V. A TOTAL SYNTHESIS OF 6-DEOXY-6-DEMETHYLTETRACYCLINE. J Am Chem Soc. 1965 Feb 20;87:933-4. PubMed PMID: 14284623.
8: Lambs L, Venturini M, Decock-Le Révérend B, Kozlowski H, Berthon G. Metal ion-tetracycline interactions in biological fluids. Part 8. Potentiometric and spectroscopic studies on the formation of Ca(II) and Mg(II) complexes with 4-dedimethylamino-tetracycline and 6-desoxy-6-demethyl-tetracycline. J Inorg Biochem. 1988 Jul;33(3):193-210. PubMed PMID: 3418341.
9: Naidong W, Hua S, Roets E, Hoogmartens J. Assay and purity control of minocycline by thin-layer chromatography using UV and fluorescence densitometry--a comparison with liquid chromatography. J Pharm Biomed Anal. 1995 Jun;13(7):905-10. PubMed PMID: 8562615.
10: Vancaillie TG, Hill RH Jr, Riehl RM, Gilstad D, Schenken RS. Laser-induced fluorescence of ectopic endometrium in rabbits. Obstet Gynecol. 1989 Aug;74(2):225-30. PubMed PMID: 2748059.
