NSC-639829 | CAS#134742-19-1 | tubulin polymerization inhibitor

MedKoo Cat#: 562141 | Name: NSC-639829

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NSC-639829 is an inhibitor of tubulin polymerization. It acts by demonstrating potent antitumor activities against several cancer cell lines.

Chemical Structure

NSC-639829

CAS#134742-19-1

Theoretical Analysis

MedKoo Cat#: 562141

Name: NSC-639829

CAS#: 134742-19-1

Chemical Formula: C21H20BrN5O3

Exact Mass: 469.0750

Molecular Weight: 470.32

Elemental Analysis: C, 53.63; H, 4.29; Br, 16.99; N, 14.89; O, 10.21

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

NSC-639829; NSC 639829; NSC639829;

IUPAC/Chemical Name

N-[[4-(5-Bromopyrimidin-2-yl)oxy-3-methylphenyl]carbamoyl]-2-(dimethylamino)benzamide

InChi Key

JNGQUJZDVFZPEN-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H20BrN5O3/c1-13-10-15(8-9-18(13)30-21-23-11-14(22)12-24-21)25-20(29)26-19(28)16-6-4-5-7-17(16)27(2)3/h4-12H,1-3H3,(H2,25,26,28,29)

SMILES Code

O=C(NC(NC1=CC=C(OC2=NC=C(Br)C=N2)C(C)=C1)=O)C3=CC=CC=C3N(C)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 470.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Balcer-Kubiczek EK, Attarpour M, Edelman MJ. The synergistic effect of dimethylamino benzoylphenylurea (NSC #639829) and X-irradiation on human lung carcinoma cell lines. Cancer Chemother Pharmacol. 2007 May;59(6):781-7. Epub 2006 Sep 7. PubMed PMID: 16957930. 2: Rao VM, Nerurkar M, Pinnamaneni S, Rinaldi F, Raghavan K. Co-solubilization of poorly soluble drugs by micellization and complexation. Int J Pharm. 2006 Aug 17;319(1-2):98-106. Epub 2006 Apr 7. PubMed PMID: 16765542. 3: Hallur G, Jimeno A, Dalrymple S, Zhu T, Jung MK, Hidalgo M, Isaacs JT, Sukumar S, Hamel E, Khan SR. Benzoylphenylurea sulfur analogues with potent antitumor activity. J Med Chem. 2006 Apr 6;49(7):2357-60. PubMed PMID: 16570932. 4: Jain A, Sanghvi T, Yalkowsky SH. Liposome formulation of NSC-639829 using halothane as a solvent: a technical note. AAPS PharmSciTech. 2003 Oct 15;4(4):E52. PubMed PMID: 15198547; PubMed Central PMCID: PMC2750645. 5: Yang G, Jain N, Yalkowsky SH. Combined effect of SLS and (SBE)(7M)-beta-CD on the solubilization of NSC-639829. Int J Pharm. 2004 Jan 9;269(1):141-8. PubMed PMID: 14698585. 6: Jain N, Yang G, Tabibi SE, Yalkowsky SH. Solubilization of NSC-639829. Int J Pharm. 2001 Aug 28;225(1-2):41-7. PubMed PMID: 11489553.