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MedKoo Cat#: 597685 | Name: L-Nabe

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L-Nabe is a potent irreversible inhibitor of endothelium dependent relaxation.

Chemical Structure

L-Nabe
L-Nabe
CAS#7672-27-7

Theoretical Analysis

MedKoo Cat#: 597685

Name: L-Nabe

CAS#: 7672-27-7

Chemical Formula: C13H19N5O4

Exact Mass: 309.1437

Molecular Weight: 309.36

Elemental Analysis: C, 50.48; H, 6.19; N, 22.64; O, 20.69

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
L-Nabe; N(w)-nitroarginine benzyl ester; NABE;
IUPAC/Chemical Name
benzyl Nw-nitro-L-argininate
InChi Key
FAJFGLZHUIUNSS-NSHDSACASA-N
InChi Code
InChI=1S/C13H19N5O4/c14-11(7-4-8-16-13(15)17-18(20)21)12(19)22-9-10-5-2-1-3-6-10/h1-3,5-6,11H,4,7-9,14H2,(H3,15,16,17)/t11-/m0/s1
SMILES Code
N[C@@H](CCCNC(N[N+]([O-])=O)=N)C(OCC1=CC=CC=C1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 309.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cheng DY, DeWitt BJ, McMahon TJ, Kadowitz PJ. Comparative effects of L-NNA and alkyl esters of L-NNA on pulmonary vasodilator responses to ACh, BK, and SP. Am J Physiol. 1994 Jun;266(6 Pt 2):H2416-22. PubMed PMID: 7517647. 2: Wayte J, Buckingham JC, Cowell AM. [3H]L-arginine transport and nitric oxide synthase activity in foetal hypothalamic cultures. Neuroreport. 1996 Dec 20;8(1):267-71. PubMed PMID: 9051793. 3: Kaye AD, Anwar M, Banister RE, Feng CJ, Turner K, Kadowitz PJ, Nossaman BD. Responses to propofol in the pulmonary vascular bed of the rat. Acta Anaesthesiol Scand. 1999 Apr;43(4):431-7. Erratum in: Acta Anaesthesiol Scand. 2016 Mar;60(3):414. Kaye, A [corrected to Kaye, A D]; Banister, R [corrected to Banister, R E]; Feng, C [corrected to Feng, C J]; Kadowitz, P [corrected to Kadowitz, P J]; Nossaman, B [corrected to Nossaman, B D]. PubMed PMID: 10225077. 4: Nossaman BD, Kaye AD, Gitlin MC, Kadowitz PJ, Feng CJ. Nomega-Nitro-L-Arginine Benzyl Ester Enhances Pulmonary Vasopressor Responses to Hypoxia and to Angiotensin II. Am J Ther. 1995 Jul;2(7):462-468. PubMed PMID: 11850692. 5: Thomas G, Ramwell PW. NW-nitro L-arginine benzyl ester, a potent irreversible inhibitor of endothelium dependent relaxation. Biochem Biophys Res Commun. 1991 Sep 30;179(3):1677-82. PubMed PMID: 1930206. 6: DeWitt BJ, Champion HC, Marrone JR, McNamara DB, Giles TD, Greenberg SS, Kadowitz PJ. Differential effects of L-N5-(1-iminoethyl)-ornithine on tone and endothelium-dependent vasodilator responses. Am J Physiol. 1997 Sep;273(3 Pt 1):L588-94. PubMed PMID: 9316493. 7: Kaye AD, Banister RE, Anwar M, Feng CJ, Kadowitz PJ, Nossaman BD. Pulmonary vasodilation by ketamine is mediated in part by L-type calcium channels. Anesth Analg. 1998 Oct;87(4):956-62. PubMed PMID: 9768801. 8: Shimizu S, Nomoto M, Yamamoto T, Momose K. Reduction by NG-nitro-L-arginine of H2O2-induced endothelial cell injury. Br J Pharmacol. 1994 Oct;113(2):564-8. PubMed PMID: 7530574; PubMed Central PMCID: PMC1510094. 9: Nossaman BD, Feng CJ, Kaye AD, DeWitt B, Coy DH, Murphy WA, Kadowitz PJ. Pulmonary vasodilator responses to adrenomedullin are reduced by NOS inhibitors in rats but not in cats. Am J Physiol. 1996 May;270(5 Pt 1):L782-9. PubMed PMID: 8967512. 10: Cernadas MR, Sánchez de Miguel L, García-Durán M, González-Fernández F, Millás I, Montón M, Rodrigo J, Rico L, Fernández P, de Frutos T, Rodríguez-Feo JA, Guerra J, Caramelo C, Casado S, López-Farré. Expression of constitutive and inducible nitric oxide synthases in the vascular wall of young and aging rats. Circ Res. 1998 Aug 10;83(3):279-86. PubMed PMID: 9710120. 11: Cheng DY, DeWitt BJ, Suzuki F, Neely CF, Kadowitz PJ. Adenosine A1 and A2 receptors mediate tone-dependent responses in feline pulmonary vascular bed. Am J Physiol. 1996 Jan;270(1 Pt 2):H200-7. PubMed PMID: 8769752. 12: Siney L, Lewis MJ. Nitric oxide release from porcine mitral valves. Cardiovasc Res. 1993 Sep;27(9):1657-61. PubMed PMID: 7506994. 13: Goureau O, Lepoivre M, Courtois Y. Lipopolysaccharide and cytokines induce a macrophage-type of nitric oxide synthase in bovine retinal pigmented epithelial cells. Biochem Biophys Res Commun. 1992 Jul 31;186(2):854-9. PubMed PMID: 1379808.

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