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MedKoo Cat#: 407860 | Name: TCJL-37
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TCJL-37 is a potent TYK2 inhibitor.

Chemical Structure

TCJL-37
TCJL-37
CAS#1258294-34-6

Theoretical Analysis

MedKoo Cat#: 407860

Name: TCJL-37

CAS#: 1258294-34-6

Chemical Formula: C17H11ClF2N4O2

Exact Mass: 376.0539

Molecular Weight: 376.75

Elemental Analysis: C, 54.20; H, 2.94; Cl, 9.41; F, 10.09; N, 14.87; O, 8.49

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
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Related CAS #
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Synonym
TCJL-37; TCJL 37; TCJL37; TC JL-37; TC JL 37; TC JL37;
IUPAC/Chemical Name
2-Chloro-4-cyano-6-fluoro-N-[2-[[[(1R,2R)-2-fluorocyclopropyl]carbonyl]amino]-4-pyridinyl]benzamide
InChi Key
NKALKXMQBFLGQI-CMPLNLGQSA-N
InChi Code
InChI=1S/C17H11ClF2N4O2/c18-11-3-8(7-21)4-13(20)15(11)17(26)23-9-1-2-22-14(5-9)24-16(25)10-6-12(10)19/h1-5,10,12H,6H2,(H2,22,23,24,25,26)/t10-,12+/m0/s1
SMILES Code
O=C(NC1=CC(NC([C@@H]2[C@H](F)C2)=O)=NC=C1)C3=C(F)C=C(C#N)C=C3Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 376.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Liang et al (2013) Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors. J.Med.Chem. 56 4521 PMID: 23668484