Sancycline | CAS#808-26-4

MedKoo Cat#: 329863 | Name: Sancycline free base

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sancycline, also known as GS-2147, is a semi-synthetic tetracycline antibiotic that is more active than tetracycline against 339 strains of anaerobic bacteria (average MIC90s = 1 and 32 μg/ml, respectively). Sancycline has been identified as a potential OTC metabolic intermediate.

Chemical Structure

Sancycline free base

CAS#808-26-4 (free base)

Theoretical Analysis

MedKoo Cat#: 329863

Name: Sancycline free base

CAS#: 808-26-4 (free base)

Chemical Formula: C21H22N2O7

Exact Mass: 414.1427

Molecular Weight: 414.41

Elemental Analysis: C, 60.86; H, 5.35; N, 6.76; O, 27.02

Price and Availability

Size	Price	Availability
5mg	USD 350.00	2 weeks
25mg	USD 575.00	2 weeks
100mg	USD 1,000.00	2 weeks

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Related CAS #

6625-20-3 (HCl) 808-26-4 (free base)

Synonym

Sancycline; 6-Demethyl-6-deoxytetracycline; GS 2147; GS-2147; GS2147; Bonomycin; NSC 51812 (as hydrochloride); Sanciclina.

IUPAC/Chemical Name

(4S,4aS,5aR,12aS)-4-(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

InChi Key

XDVCLKFLRAWGIT-ADOAZJKMSA-N

InChi Code

InChI=1S/C21H22N2O7/c1-23(2)15-10-7-9-6-8-4-3-5-11(24)12(8)16(25)13(9)18(27)21(10,30)19(28)14(17(15)26)20(22)29/h3-5,9-10,15,24,26-27,30H,6-7H2,1-2H3,(H2,22,29)/t9-,10-,15-,21-/m0/s1

SMILES Code

O=C(C(C1=O)=C(O)[C@@H](N(C)C)[C@]2([H])C[C@]3([H])CC4=C(C(C3=C(O)[C@@]21O)=O)C(O)=CC=C4)N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Sancycline exhibits higher activity than tetracycline against a broad spectrum of anaerobic bacteria, with particularly low MIC values (1 and 32 μg/ml, respectively). It also remains effective against tetracycline-resistant E. coli, S. aureus, and E. faecalis strains, with MICs ranging from 0.06 to 1 μg/ml. In vivo, sancycline demonstrates efficacy against S. aureus in mice, with ED50 values of 0.46 and 0.6 mg/kg for intravenous and subcutaneous administration, respectively.

In vitro activity:

To be determined

In vivo activity:

To be determined

	Solvent	mg/mL	mM
Solubility
	DMF	0.3	0.72
	DMSO	3.0	7.24

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 414.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

To be determined

In vitro protocol:

To be determined

In vivo protocol:

To be determined

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