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MedKoo Cat#: 529534 | Name: Bedoradrine sulfate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bedoradrine sulfate is a β2-adrenoceptor agonist potentially for the treatment of asthma.

Chemical Structure

Bedoradrine sulfate
Bedoradrine sulfate
CAS#194785-31-4 (sulfate)

Theoretical Analysis

MedKoo Cat#: 529534

Name: Bedoradrine sulfate

CAS#: 194785-31-4 (sulfate)

Chemical Formula: C24H34N2O9S

Exact Mass:

Molecular Weight: 526.60

Elemental Analysis: C, 54.74; H, 6.51; N, 5.32; O, 27.34; S, 6.09

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
194785-19-8 (free base) 194785-31-4 (sulfate) 1338644-26-0 (fumarate) 1338644-30-6 (mesylate)
Synonym
Bedoradrine sulfate; Bedoradrine; MN-221; KUR-1246; MN221; KUR1246; MN 221; KUR 1246
IUPAC/Chemical Name
2-(((S)-7-(((R)-2-hydroxy-2-(4-hydroxy-3-(2-hydroxyethyl)phenyl)ethyl)amino)-5,6,7,8-tetrahydronaphthalen-2-yl)oxy)-N,N-dimethylacetamide sulfate
InChi Key
BIBSCYWSUFOPGZ-WCRWPNQISA-N
InChi Code
InChI=1S/C24H32N2O5.H2O4S/c1-26(2)24(30)15-31-21-7-4-16-3-6-20(12-19(16)13-21)25-14-23(29)17-5-8-22(28)18(11-17)9-10-27;1-5(2,3)4/h4-5,7-8,11,13,20,23,25,27-29H,3,6,9-10,12,14-15H2,1-2H3;(H2,1,2,3,4)/t20-,23-;/m0./s1
SMILES Code
O=C(N(C)C)COC1=CC=C2CC[C@H](NC[C@H](O)C3=CC=C(O)C(CCO)=C3)CC2=C1.O=S(O)(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 526.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Matsuda K, Makhay M, Johnson K, Iwaki Y. Evaluation of bedoradrine sulfate (MN-221), a novel, highly selective beta2-adrenergic receptor agonist for the treatment of asthma via intravenous infusion. J Asthma. 2012 Dec;49(10):1071-8. doi: 10.3109/02770903.2012.729631. PubMed PMID: 23094708. 2: House SL, Matsuda K, O'Brien G, Makhay M, Iwaki Y, Ferguson I, Lovato LM, Lewis LM. Efficacy of a new intravenous β2-adrenergic agonist (bedoradrine, MN-221) for patients with an acute exacerbation of asthma. Respir Med. 2015 Oct;109(10):1268-73. doi: 10.1016/j.rmed.2015.08.003. PubMed PMID: 26324315. 3: Antoniu S. Bedoradrine for treating asthma and chronic obstructive pulmonary disease. Expert Opin Investig Drugs. 2014 Aug;23(8):1149-56. doi: 10.1517/13543784.2014.928284. Review. PubMed PMID: 24938936. 4: Inoue Y, Yoshizato T, Kawarabayashi T. Investigation of beta(2)-adrenoceptor subtype selectivity and organ specificity for bedoradrine (KUR-1246), a novel tocolytic beta-adrenergic receptor stimulant. J Obstet Gynaecol Res. 2009 Jun;35(3):405-13. doi: 10.1111/j.1447-0756.2008.01001.x. PubMed PMID: 19527375. 5: Travers AH, Milan SJ, Jones AP, Camargo CA Jr, Rowe BH. Addition of intravenous beta(2)-agonists to inhaled beta(2)-agonists for acute asthma. Cochrane Database Syst Rev. 2012 Dec 12;12:CD010179. doi: 10.1002/14651858.CD010179. Review. PubMed PMID: 23235685. 6: Gross N. The COPD pipeline XX. COPD. 2013 Feb;10(1):104-6. doi: 10.3109/15412555.2013.766103. PubMed PMID: 23413896. 7: Furihata Y, Kobayashi M, Kojima M, Kobayashi K, Kawarabayashi T, Yamamoto T. Effects of KUR-1246, a selective uterine relaxant, on transplacental passage and transmigration to milk. J Obstet Gynaecol Res. 2006 Feb;32(1):4-9. PubMed PMID: 16445519. 8: Furihata Y, Motokawa Y, Murata S, Kiguchi S, Kobayashi M, Murakami M, Kojima M, Yamamoto T. Cardiovascular effects of KUR-1246, a new tetrahydronaphthalen derivative beta2-adrenoceptor agonist and a selective uterine relaxant. Arzneimittelforschung. 2006;56(1):18-24. PubMed PMID: 16478001. 9: Murata S, Matsuda T, Kiguchi S, Kobayashi M, Cho K, Okuyama K. Effects of long term administration of KUR-1246, a selective beta(2)-adrenoceptor agonist, on pregnant sheep and their fetuses. BJOG. 2005 Jan;112(1):69-74. PubMed PMID: 15663400. 10: Kiguchi S, Matsuda T, Cho K, Okuyama K, Akahane M, Fujimoto S. KUR-1246, a novel beta(2)-adrenoceptor agonist, as a tocolytic agent. Obstet Gynecol. 2002 Sep;100(3):487-94. PubMed PMID: 12220768. 11: Sakakibara T, Inoue Y, Uzue S, Tsukamoto T, Kobayashi M, Kojima M, Akahane M, Kitamura K, Kawarabayashi T. Diversity of inhibitory responses to beta2-stimulants shown by term-pregnant human myometria in vitro is partly due to differences in receptor density. Am J Obstet Gynecol. 2002 May;186(5):997-1004. PubMed PMID: 12015527. 12: Yanagi T, Kikuchi K, Takeuchi H, Ishikawa T, Nishimura T, Yamamoto I. The practical synthesis of a uterine relaxant, bis(2-[[(2S)-2-([(2R)-2-hydroxy-2-[4-hydroxy-3-(2-hydroxyethyl)-phenyl]ethyl]amin o)-1,2,3,4-tetrahydronaphthalen-7-yl]oxy]-N,N-dimethylacetamide) sulfate (KUR-1246). Chem Pharm Bull (Tokyo). 2001 Aug;49(8):1018-23. PubMed PMID: 11515570. 13: Kobayashi M, Takeda K, Murata S, Kojima M, Akahane M, Inoue Y, Kitamura K, Kawarabayashi T. Pharmacological characterization of KUR-1246, a selective uterine relaxant. J Pharmacol Exp Ther. 2001 May;297(2):666-71. PubMed PMID: 11303056.