MTT5 is a toll-like receptor 7 (TLR7) agonist.
MedKoo Cat#: 129077
Name: MTT5
CAS#: N/A
Chemical Formula: C22H27N7O4
Exact Mass: 453.2125
Molecular Weight: 453.50
Elemental Analysis: C, 58.27; H, 6.00; N, 21.62; O, 14.11
The following data is based on the product molecular weight 453.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Zhou H, Xu J, Wang W. Functional analysis of metallothionein MTT5 from
Tetrahymena thermophila. J Cell Biochem. 2018 Apr;119(4):3257-3266. doi:
10.1002/jcb.26482. Epub 2018 Jan 15. PMID: 29091311.
2: Yue H, Xu H, Ma L, Li X, Yang B, Wang X, Zeng Q, Li H, Zhang D, Geng M, Meng
T, Xie Z. A DXd/TLR7-Agonist Dual-Conjugate Anti-HER2 ADC Exerts Robust
Antitumor Activity Through Tumor Cell Killing and Immune Activation. Mol Cancer
Ther. 2024 Nov 4;23(11):1639-1651. doi: 10.1158/1535-7163.MCT-24-0078. PMID:
39082754.
3: Lu CW, Ho HC, Yao CL, Tseng TY, Kao CM, Chen SC. Bioremediation potential of
cadmium by recombinant Escherichia coli surface expressing metallothionein MTT5
from Tetrahymenathermophila. Chemosphere. 2023 Jan;310:136850. doi:
10.1016/j.chemosphere.2022.136850. Epub 2022 Oct 12. PMID: 36243083.
4: Formigari A, Boldrin F, Santovito G, Cassidy-Hanley D, Clark TG, Piccinni E.
Functional characterization of the 5'-upstream region of MTT5 metallothionein
gene from Tetrahymena thermophila. Protist. 2010 Jan;161(1):71-7. doi:
10.1016/j.protis.2009.06.002. Epub 2009 Aug 11. PMID: 19674934.
5: Gualandris D, Rotondo D, Lorusso C, La Terza A, Calisi A, Dondero F. The
Metallothionein System in <i>Tetrahymena thermophila</i> Is Iron-Inducible.
Toxics. 2024 Oct 8;12(10):725. doi: 10.3390/toxics12100725. PMID: 39453145;
PMCID: PMC11511230.
6: Díaz S, Amaro F, Rico D, Campos V, Benítez L, Martín-González A, Hamilton EP,
Orias E, Gutiérrez JC. Tetrahymena metallothioneins fall into two discrete
subfamilies. PLoS One. 2007 Mar 14;2(3):e291. doi: 10.1371/journal.pone.0000291.
PMID: 17356700; PMCID: PMC1808422.
7: Zhao SH, Hu KK, Xiong J, Tu JW, Miao W. Simultaneous removal and optical
determination of mercury ions by constructing fluorescent recombinant T.
thermophila SB210 strains. Ecotoxicol Environ Saf. 2025 Jun 15;298:118325. doi:
10.1016/j.ecoenv.2025.118325. Epub 2025 May 17. PMID: 40383066.
8: Espart A, Marín M, Gil-Moreno S, Palacios Ò, Amaro F, Martín-González A,
Gutiérrez JC, Capdevila M, Atrian S. Hints for metal-preference protein sequence
determinants: different metal binding features of the five tetrahymena
thermophila metallothioneins. Int J Biol Sci. 2015 Mar 18;11(4):456-71. doi:
10.7150/ijbs.11060. PMID: 25798065; PMCID: PMC4366644.
9: Wang L, Wang Y, Dai S, Wang B. Surface Display of Multiple Metal-Binding
Domains in <i>Deinococcus radiodurans</i> Alleviates Cadmium and Lead Toxicity
in Rice. Int J Mol Sci. 2024 Nov 22;25(23):12570. doi: 10.3390/ijms252312570.
PMID: 39684280; PMCID: PMC11640945.
10: de Francisco P, Martín-González A, Turkewitz AP, Gutiérrez JC. Extreme metal
adapted, knockout and knockdown strains reveal a coordinated gene expression
among different Tetrahymena thermophila metallothionein isoforms. PLoS One. 2017
Dec 5;12(12):e0189076. doi: 10.1371/journal.pone.0189076. PMID: 29206858; PMCID:
PMC5716537.
