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MedKoo Cat#: 575567 | Name: FP-PPA

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FP-PPA is the ester moiety of flurbiprofen and a histamine H2 receptor blockader. FP-PPA causes less gastric damage than the methyl ester of flurbiprofen or flurbiprofen itself.

Chemical Structure

FP-PPA
FP-PPA
CAS#135497-86-8

Theoretical Analysis

MedKoo Cat#: 575567

Name: FP-PPA

CAS#: 135497-86-8

Chemical Formula: C34H41FN2O4S

Exact Mass: 592.2771

Molecular Weight: 592.77

Elemental Analysis: C, 68.89; H, 6.97; F, 3.21; N, 4.73; O, 10.80; S, 5.41

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
FP-PPA
IUPAC/Chemical Name
(1,1'-Biphenyl)-4-acetic acid, 2-fluoro-alpha-methyl-, 2-((-2-oxo-2-((3-(3-(1-piperidinylmethyl)phenoxy)propyl)amino)ethyl)thio)ethyl ester
InChi Key
BVNYGFVUPRMYKJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C34H41FN2O4S/c1-26(29-14-15-31(32(35)23-29)28-11-4-2-5-12-28)34(39)41-20-21-42-25-33(38)36-16-9-19-40-30-13-8-10-27(22-30)24-37-17-6-3-7-18-37/h2,4-5,8,10-15,22-23,26H,3,6-7,9,16-21,24-25H2,1H3,(H,36,38)
SMILES Code
CC(C(=O)OCCSCC(=O)NCCCOc1cccc(CN2CCCCC2)c1)c3ccc(c(F)c3)c4ccccc4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 592.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Fukuhara A, Imai T, Otagiri M. Stereoselective disposition of flurbiprofen from a mutual prodrug with a histamine H2-antagonist to reduce gastrointestinal lesions in the rat. Chirality. 1996;8(7):494-502. doi: 10.1002/(SICI)1520-636X(1996)8:7<494::AID-CHIR6>3.0.CO;2-B. PMID: 8970747. 2. Imai T, Fukuhara A, Ueda I, Otagiri M. An evaluation of an anti-inflammatory-histamine H2 antagonist drug complex on gastric erosions in the rat. J Pharmacol Exp Ther. 1993 Apr;265(1):328-33. PMID: 8097246. 3. Fukuhara A, Imai T, Inoue K, Otagiri M. Effect of oral multiple-dose administration of anti-inflammatory flurbiprofen chimera drug on gastric lesion, other toxicities and disposition kinetics. Biol Pharm Bull. 1995 Jan;18(1):140-7. doi: 10.1248/bpb.18.140. PMID: 7735229.