Ac3Az11 is a potent MRP1 inhibitor. Ac3Az11 was predicted to bind to the bipartite substrate-binding site of MRP1 in a competitive manner. Moreover, it provided sufficient concentration to maintain its plasma level above its in vitro EC50 (53 nM for DOX) for about 90 min.
MedKoo Cat#: 407941
Name: Ac3Az11
CAS#: Unknown
Chemical Formula: C39H32FN3O7
Exact Mass: 673.2224
Molecular Weight: 673.70
Elemental Analysis: C, 69.53; H, 4.79; F, 2.82; N, 6.24; O, 16.62
The following data is based on the product molecular weight 673.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
