MedKoo Cat#: 577827 | Name: Bedoradrine free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bedoradrine is a β2-adrenoceptor agonist potentially for the treatment of asthma.

Chemical Structure

Bedoradrine free base
Bedoradrine free base
CAS#194785-19-8 (free base)

Theoretical Analysis

MedKoo Cat#: 577827

Name: Bedoradrine free base

CAS#: 194785-19-8 (free base)

Chemical Formula: C24H32N2O5

Exact Mass: 428.2311

Molecular Weight: 428.53

Elemental Analysis: C, 67.27; H, 7.53; N, 6.54; O, 18.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
194785-19-8 (free base) 194785-31-4 (sulfate) 1338644-26-0 (fumarate) 1338644-30-6 (mesylate)
Synonym
Bedoradrine; MN-221; KUR-1246; MN221; KUR1246; MN 221; KUR 1246
IUPAC/Chemical Name
N,N-Dimethyl-2-[[(7S)-5,6,7,8-tetrahydro-7-[[(2R)-2-hydroxy-2-[4-hydroxy-3-(2-hydroxyethyl)phenyl]ethyl]amino]-2-naphthalenyl]oxy]acetamide
InChi Key
OANCEOSLKSTLTA-REWPJTCUSA-N
InChi Code
InChI=1S/C24H32N2O5/c1-26(2)24(30)15-31-21-7-4-16-3-6-20(12-19(16)13-21)25-14-23(29)17-5-8-22(28)18(11-17)9-10-27/h4-5,7-8,11,13,20,23,25,27-29H,3,6,9-10,12,14-15H2,1-2H3/t20-,23-/m0/s1
SMILES Code
O=C(N(C)C)COC1=CC=C2CC[C@H](NC[C@H](O)C3=CC=C(O)C(CCO)=C3)CC2=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 428.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Matsuda K, Makhay M, Johnson K, Iwaki Y. Evaluation of bedoradrine sulfate (MN-221), a novel, highly selective beta2-adrenergic receptor agonist for the treatment of asthma via intravenous infusion. J Asthma. 2012 Dec;49(10):1071-8. doi: 10.3109/02770903.2012.729631. PubMed PMID: 23094708. 2: House SL, Matsuda K, O'Brien G, Makhay M, Iwaki Y, Ferguson I, Lovato LM, Lewis LM. Efficacy of a new intravenous β2-adrenergic agonist (bedoradrine, MN-221) for patients with an acute exacerbation of asthma. Respir Med. 2015 Oct;109(10):1268-73. doi: 10.1016/j.rmed.2015.08.003. PubMed PMID: 26324315. 3: Antoniu S. Bedoradrine for treating asthma and chronic obstructive pulmonary disease. Expert Opin Investig Drugs. 2014 Aug;23(8):1149-56. doi: 10.1517/13543784.2014.928284. Review. PubMed PMID: 24938936.