Imiloxan free base | CAS#81167-16-0 | α2 antagonist

MedKoo Cat#: 328040 | Name: Imiloxan free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Imiloxan, also known as RS-21361, is an α2 adrenergic receptor antagonist potentially for the treatment of major depressive disorder.

Chemical Structure

Imiloxan free base

CAS#81167-16-0 (free base)

Theoretical Analysis

MedKoo Cat#: 328040

Name: Imiloxan free base

CAS#: 81167-16-0 (free base)

Chemical Formula: C14H16N2O2

Exact Mass: 244.1212

Molecular Weight: 244.29

Elemental Analysis: C, 68.83; H, 6.60; N, 11.47; O, 13.10

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

81167-16-0 (free base) 86710-23-8 (HCl) 81167-22-8 (HCl)

Synonym

Imiloxan; RS-21361; RS 21361; RS21361.

IUPAC/Chemical Name

2-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-1-ethyl-1H-imidazole

InChi Key

UXABARREKCJULM-UHFFFAOYSA-N

InChi Code

InChI=1S/C14H16N2O2/c1-2-16-8-7-15-14(16)9-11-10-17-12-5-3-4-6-13(12)18-11/h3-8,11H,2,9-10H2,1H3

SMILES Code

CCN1C=CN=C1CC2OC3=CC=CC=C3OC2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Related CAS# 86710-23-8 (Imiloxan hydrochloride ) 81167-16-0 (Imiloxan free base)

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 244.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Fitch WL, Chen Y, Liu L, Paehler A, Young M. Application of modern drug metabolism structure determination tools and assays to the in vitro metabolism of imiloxan. Drug Metab Lett. 2010 Apr;4(2):77-87. PubMed PMID: 20446913. 2: Takano Y, Takano M, Yaksh TL. The effect of intrathecally administered imiloxan and WB4101: possible role of alpha 2-adrenoceptor subtypes in the spinal cord. Eur J Pharmacol. 1992 Sep 4;219(3):465-8. PubMed PMID: 1358645. 3: Rush WR, Hall DJ, Graham DJ, Selby IA. The metabolism of imiloxan hydrochloride in healthy male volunteers. Xenobiotica. 1992 Feb;22(2):237-46. PubMed PMID: 1352928. 4: Michel AD, Loury DN, Whiting RL. Assessment of imiloxan as a selective alpha 2B-adrenoceptor antagonist. Br J Pharmacol. 1990 Mar;99(3):560-4. PubMed PMID: 1970500; PubMed Central PMCID: PMC1917331.