Opnurasib, also known as JDQ443, NVP-JDQ443, is a novel KRASG12C inhibitor which binds under the switch II loop with a novel binding mode, exploiting unique interactions with the KRASG12C protein compared to Sotorasib and Adagrasib. JDQ443 potently inhibits KRASG12C cellular signaling and proliferation in a mutant selective manner by irreversibly trapping the GDP-bound state of KRASG12C through formation of a covalent bond with cysteine at position 12.
MedKoo Cat#: 465765
Name: Opnurasib
CAS#: 2653994-08-0
Chemical Formula: C29H28ClN7O
Exact Mass: 525.2044
Molecular Weight: 526.04
Elemental Analysis: C, 66.22; H, 5.37; Cl, 6.74; N, 18.64; O, 3.04
The following data is based on the product molecular weight 526.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
