MedKoo Cat#: 576630 | Name: Imiloxan HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Imiloxan, also known as RS-21361, is an α2 adrenergic receptor antagonist potentially for the treatment of major depressive disorder.

Chemical Structure

Imiloxan HCl
Imiloxan HCl
CAS#81167-22-8 (HCl)

Theoretical Analysis

MedKoo Cat#: 576630

Name: Imiloxan HCl

CAS#: 81167-22-8 (HCl)

Chemical Formula: C14H17ClN2O2

Exact Mass: 0.0000

Molecular Weight: 280.75

Elemental Analysis: C, 59.89; H, 6.10; Cl, 12.63; N, 9.98; O, 11.40

Price and Availability

Size Price Availability Quantity
50mg USD 550.00 2 Weeks
100mg USD 950.00 2 Weeks
200mg USD 1,450.00 2 Weeks
500mg USD 2,950.00 2 Weeks
1g USD 4,650.00 2 Weeks
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Related CAS #
Synonym
Imiloxan hydrochloride; Imiloxan HCl; RS-21361; RS 21361; RS21361
IUPAC/Chemical Name
(+-)-2-(1,4-Benzodioxan-2-ylmethyl)-1-ethylimidazole monohydrochloride
InChi Key
ANDJPJNFVJXEKX-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H16N2O2.ClH/c1-2-16-8-7-15-14(16)9-11-10-17-12-5-3-4-6-13(12)18-11;/h3-8,11H,2,9-10H2,1H3;1H
SMILES Code
Cl.CCn1ccnc1CC2COc3ccccc3O2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 280.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Fitch WL, Chen Y, Liu L, Paehler A, Young M. Application of modern drug metabolism structure determination tools and assays to the in vitro metabolism of imiloxan. Drug Metab Lett. 2010 Apr;4(2):77-87. PubMed PMID: 20446913. 2: Takano Y, Takano M, Yaksh TL. The effect of intrathecally administered imiloxan and WB4101: possible role of alpha 2-adrenoceptor subtypes in the spinal cord. Eur J Pharmacol. 1992 Sep 4;219(3):465-8. PubMed PMID: 1358645. 3: Rush WR, Hall DJ, Graham DJ, Selby IA. The metabolism of imiloxan hydrochloride in healthy male volunteers. Xenobiotica. 1992 Feb;22(2):237-46. PubMed PMID: 1352928. 4: Michel AD, Loury DN, Whiting RL. Assessment of imiloxan as a selective alpha 2B-adrenoceptor antagonist. Br J Pharmacol. 1990 Mar;99(3):560-4. PubMed PMID: 1970500; PubMed Central PMCID: PMC1917331.