MedKoo Cat#: 524962 | Name: Difenamizole

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Difenamizole is a non-steroidal anti-inflammatory drug (NSAID) and analgesic of the pyrazolone group related to metamizole. It has monoaminergic properties, including inhibition of monoamine oxidase, augmentation of pargyline-induced elevation of striatal dopamine levels, inhibition of K+-induced striatal dopamine release, and inhibition of the reuptake of dopamine.

Chemical Structure

Difenamizole
CAS#20170-20-1 (free base)

Theoretical Analysis

MedKoo Cat#: 524962

Name: Difenamizole

CAS#: 20170-20-1 (free base)

Chemical Formula: C20H22N4O

Exact Mass: 334.1794

Molecular Weight: 334.41

Elemental Analysis: C, 71.83; H, 6.63; N, 16.75; O, 4.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Difenamizole; Difenamizole [INN]; Difenamizolum; BRN 0698538; Diphenamizole; Pasalin; UNII-24MR6YLL3W.
IUPAC/Chemical Name
1,3-Diphenyl-5-(2-dimethylaminopropionamido)pyrazole
InChi Key
PCXMKBOWWVXEDT-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H22N4O/c1-15(23(2)3)20(25)21-19-14-18(16-10-6-4-7-11-16)22-24(19)17-12-8-5-9-13-17/h4-15H,1-3H3,(H,21,25)
SMILES Code
CC(C(=O)Nc1cc(nn1c2ccccc2)c3ccccc3)N(C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 334.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kameyama T, Nabeshima T, Yoshida N, Yamaguchi K. Neurochemical studies of an analgesic, 1,3-diphenyl-5-(2-dimethylaminopropionamide)-pyrazole [difenamizole]. Res Commun Chem Pathol Pharmacol. 1981 Jan;31(1):31-53. PubMed PMID: 6454942. 2: Kameyama T, Ukai M, Nabeshima T. Inhibitory effect of difenamizole on morphine-induced straub tail reaction with special reference to monoaminergic agents. Chem Pharm Bull (Tokyo). 1978 Nov;26(11):3265-70. PubMed PMID: 729114. 3: Nabeshima T, Yamaguchi K, Kameyama T. Effects of difenamizole on content of catecholamines and metabolites in mouse brain. Jpn J Pharmacol. 1978 Aug;28(4):642-6. PubMed PMID: 732046. 4: Kameyama T, Nabeshima T. Effects of 1,3-diphenyl-5-(2-dimethylaminopropionamide)-pyrazole[difenamizole] on a conditioned avoidance response. Neuropharmacology. 1978 Apr-May;17(4-5):249-56. PubMed PMID: 652137. 5: Nabeshima T, Kameyama T. [Effects of difenamizole on behavior maintained by schedule of positive reinforcement (author's transl)]. Nihon Yakurigaku Zasshi. 1977 Nov;73(8):961-72. Japanese. PubMed PMID: 611070. 6: Nabeshima T, Ina M, Kameyama T. [Effect of monoamine-related drugs on inhibitory action of difenamizole to acetic acid-induced writhing in mice (author's transl)]. Nihon Yakurigaku Zasshi. 1977 Nov;73(8):907-17. Japanese. PubMed PMID: 611067. 7: Kameyama T, Nabeshima T. [Relationship between biogenic amines and analgesic action of difenamizole in heat induced reflexes]. Nihon Yakurigaku Zasshi. 1976 Jul;72(5):543-56. Japanese. PubMed PMID: 136390.