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MedKoo Cat#: 414980 | Name: Piquizil Free Base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Piquizil Free Base, a 4-aminoquinazoline causing relaxation of respiratory smooth muscle in animals, appeared to be a bronchodilator in man.

Chemical Structure

Piquizil Free Base
Piquizil Free Base
CAS#21560-58-7 (free base)

Theoretical Analysis

MedKoo Cat#: 414980

Name: Piquizil Free Base

CAS#: 21560-58-7 (free base)

Chemical Formula: C19H26N4O4

Exact Mass: 374.1954

Molecular Weight: 374.44

Elemental Analysis: C, 60.95; H, 7.00; N, 14.96; O, 17.09

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
21560-58-7 (free base); 23256-26-0 (HCl)
Synonym
Piquizil Free Base
IUPAC/Chemical Name
COc1cc2ncnc(N3CCN(CC3)C(=O)OCC(C)C)c2cc1OC
InChi Key
NXVJUZJOJFBHLG-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H26N4O4/c1-13(2)11-27-19(24)23-7-5-22(6-8-23)18-14-9-16(25-3)17(26-4)10-15(14)20-12-21-18/h9-10,12-13H,5-8,11H2,1-4H3
SMILES Code
COc(c1)c(OC)cc2c1ncnc2N3CCN(C(OCC(C)C)=O)CC3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 374.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Schach von Wittenau M, Brewer TF. Quinazolines in man. Metabolism and preliminary evaluation of piquizil and hoquizil, two bronchodilators. Pharmacology. 1971;6(3):173-85. doi: 10.1159/000136240. PMID: 4946165.