MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 526629 | Name: MK-8718

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MK-8718 is a potent, selective and orally bioavailable HIV protease inhibitor with a favorable pharmacokinetic profile with potential for further development.

Chemical Structure

MK-8718
MK-8718
CAS#1582729-24-5 (free base)

Theoretical Analysis

MedKoo Cat#: 526629

Name: MK-8718

CAS#: 1582729-24-5 (free base)

Chemical Formula: C30H30ClF6N5O4

Exact Mass: 673.1891

Molecular Weight: 674.04

Elemental Analysis: C, 53.46; H, 4.49; Cl, 5.26; F, 16.91; N, 10.39; O, 9.49

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
1582729-24-5 (free base) 1582732-29-3 (HCl)
Synonym
MK-8718; MK 8718; MK8718.
IUPAC/Chemical Name
((3S,6R)-6-(2-(3-((2S,3S)-2-amino-3-(4-chlorophenyl)-3-(3,5-difluorophenyl)propanamido)-5-fluoropyridin-4-yl)ethyl)morpholin-3-yl)methyl (2,2,2-trifluoroethyl)carbamate
InChi Key
OUUHZXOSBUCFJO-ZKBLBJRCSA-N
InChi Code
InChI=1S/C30H30ClF6N5O4/c31-18-3-1-16(2-4-18)26(17-7-19(32)9-20(33)8-17)27(38)28(43)42-25-12-39-11-24(34)23(25)6-5-22-10-40-21(13-45-22)14-46-29(44)41-15-30(35,36)37/h1-4,7-9,11-12,21-22,26-27,40H,5-6,10,13-15,38H2,(H,41,44)(H,42,43)/t21-,22+,26-,27-/m0/s1
SMILES Code
O=C(OC[C@H]1NC[C@@H](CCC(C(F)=CN=C2)=C2NC([C@@H](N)[C@@H](C3=CC=C(Cl)C=C3)C4=CC(F)=CC(F)=C4)=O)OC1)NCC(F)(F)F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 674.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Discovery of MK-8718, an HIV Protease Inhibitor Containing a Novel Morpholine Aspartate Binding Group Christopher J. Bungard*†, Peter D. Williams†, Jeanine E. Ballard†, David J. Bennett†, Christian Beaulieu‡, Carolyn Bahnck-Teets†, Steve S. Carroll†, Ronald K. Chang†, David C. Dubost†, John F. Fay†, Tracy L. Diamond†, Thomas J. Greshock†, Li Hao§, M. Katharine Holloway†, Peter J. Felock, Jennifer J. Gesell†, Hua-Poo Su†, Jesse J. Manikowski†, Daniel J. McKay‡, Mike Miller†, Xu Min†, Carmela Molinaro†, Oscar M. Moradei‡, Philippe G. Nantermet†, Christian Nadeau‡, Rosa I. Sanchez†, Tummanapalli Satyanarayana§, William D. Shipe†, Sanjay K. Singh§, Vouy Linh Truong‡, Sivalenka Vijayasaradhi§, Catherine M. Wiscount†, Joseph P. Vacca‡, Sheldon N. Crane‡, and John A. McCauley† † Merck Research Laboratories, 770 Sumneytown Pike, PO Box 4, West Point, Pennsylvania 19486, United States ‡ Merck Frosst Centre for Therapeutic Research, 16711 TransCanada Highway, Kirkland, Quebec H9H 3L1, Canada § Albany Molecular Research Singapore Research Center, 61 Science Park Road #05-01, The Galen Singapore Science Park II, Singapore 117525 ACS Med. Chem. Lett., Article ASAP DOI: 10.1021/acsmedchemlett.6b00135 Publication Date (Web): May 09, 2016