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MedKoo Cat#: 412636 | Name: CGC 11093

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CGC 11093 is a polyamine analog; inhibits growth of human prostate tumor xenografts in nude mice. It may prove useful in promoting regression of choroidal neovascularization.

Chemical Structure

CGC 11093
CGC 11093
CAS#306292-64-8

Theoretical Analysis

MedKoo Cat#: 412636

Name: CGC 11093

CAS#: 306292-64-8

Chemical Formula: C17H42Cl4N4

Exact Mass: 442.2164

Molecular Weight: 444.35

Elemental Analysis: C, 45.95; H, 9.53; Cl, 31.91; N, 12.61

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CGC 11093; CGC11093; CGC-11093
IUPAC/Chemical Name
1,2-Cyclopropanedimethanamine, N,N'-bis(4-(ethylamino)butyl)-, tetrahydrochloride, (1R,2R)-rel-
InChi Key
AXRCRLGWQBZVSB-LWTACFFUSA-N
InChi Code
InChI=1S/C17H38N4.4ClH/c1-3-18-9-5-7-11-20-14-16-13-17(16)15-21-12-8-6-10-19-4-2;;;;/h16-21H,3-15H2,1-2H3;4*1H/t16-,17-;;;;/m0..../s1
SMILES Code
CCNCCCCNC[C@H]1[C@H](CNCCCCNCC)C1.[H]Cl.[H]Cl.[H]Cl.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 444.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Carew JS, Nawrocki ST, Reddy VK, Bush D, Rehg JE, Goodwin A, Houghton JA, Casero RA Jr, Marton LJ, Cleveland JL. The novel polyamine analogue CGC-11093 enhances the antimyeloma activity of bortezomib. Cancer Res. 2008 Jun 15;68(12):4783-90. doi: 10.1158/0008-5472.CAN-07-6483. PMID: 18559525; PMCID: PMC2749595. 2: Lima e Silva R, Kachi S, Akiyama H, Shen J, Hatara MC, Aslam S, Gong YY, Khu NH, Lauer TW, Hackett SF, Marton LJ, Campochiaro PA. Trans-scleral delivery of polyamine analogs for ocular neovascularization. Exp Eye Res. 2006 Nov;83(5):1260-7. doi: 10.1016/j.exer.2006.07.003. Epub 2006 Sep 6. PMID: 16950258. 3: Ignatenko NA, Yerushalmi HF, Watts GS, Futscher BW, Stringer DE, Marton LJ, Gerner EW. Pharmacogenomics of the polyamine analog 3,8,13,18-tetraaza-10,11-[(E)-1,2-cyclopropyl]eicosane tetrahydrochloride, CGC-11093, in the colon adenocarcinoma cell line HCT1161. Technol Cancer Res Treat. 2006 Dec;5(6):553-64. doi: 10.1177/153303460600500602. PMID: 17121431. 4: Loussouarn G, Marton LJ, Nichols CG. Molecular basis of inward rectification: structural features of the blocker defined by extended polyamine analogs. Mol Pharmacol. 2005 Aug;68(2):298-304. doi: 10.1124/mol.105.012377. Epub 2005 May 4. PMID: 15872118.