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MedKoo Cat#: 318499 | Name: Pipotiazine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pipotiazine has actions similar to those of other phenothiazines. Among the different phenothiazine derivatives, it is less sedating and to have a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics. However, it produces a high incidence of extra pyramidal reactions. It is used for the maintenance treatment of chronic non-agitated schizophrenic patients.

Chemical Structure

Pipotiazine
Pipotiazine
CAS#39860-99-6

Theoretical Analysis

MedKoo Cat#: 318499

Name: Pipotiazine

CAS#: 39860-99-6

Chemical Formula: C24H33N3O3S2

Exact Mass: 475.1963

Molecular Weight: 475.67

Elemental Analysis: C, 60.60; H, 6.99; N, 8.83; O, 10.09; S, 13.48

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Pipotiazine; Pipothiazine; Pipotiazina; Pipotiazinum; Piportil L4; 19366 RP; 19366-RP; pipothiazine; pipotiazin; RP 19366; RP-19366;
IUPAC/Chemical Name
10-[3-[4-(2-hydroxyethyl)piperidin-1-yl]propyl]-N,N-dimethylphenothiazine-2-sulfonamide
InChi Key
JOMHSQGEWSNUKU-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H33N3O3S2/c1-25(2)32(29,30)20-8-9-24-22(18-20)27(21-6-3-4-7-23(21)31-24)14-5-13-26-15-10-19(11-16-26)12-17-28/h3-4,6-9,18-19,28H,5,10-17H2,1-2H3
SMILES Code
CN(C)S(=O)(=O)C1=CC2=C(C=C1)SC3=CC=CC=C3N2CCCN4CCC(CC4)CCO
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 475.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Dinesh M, David A, Quraishi SN. Depot pipotiazine palmitate and undecylenate for schizophrenia. Cochrane Database Syst Rev. 2004 Oct 18;(4):CD001720. Review. PubMed PMID: 15495016. 2: De Schepper PJ, Vranckx C, Verbeeck R, Van den Berghe ML. Pipotiazine pharmacokinetics after p.o. and i.v. administration in man. Correlation between blood levels and effect on the handwriting area. Arzneimittelforschung. 1979;29(7):1056-62. PubMed PMID: 40577. 3: Scatton B, Boireau A, Garret C, Glowinski J, Julou L. Action of the palmitic ester of pipotiazine on dopamine metabolism in the nigro-striatal, meso-limbic and meso-cortiacal systems. Naunyn Schmiedebergs Arch Pharmacol. 1977 Jan;296(2):169-75. PubMed PMID: 13318. 4: Gallant DM, Mielke D, Bishop G, Oelsner T, Guerrero-Figueroa R. Pipotiazine palmitate: an evaluation of a new long acting intramuscular antipsychotic agent in severely ill schizophrenic patients. Dis Nerv Syst. 1975 Apr;36(4):193-6. PubMed PMID: 1090427. 5: Simpson GM, Varga V. Pipotiazine palmitate: a new depot neuroleptic. Curr Ther Res Clin Exp. 1975 Mar;17(3):276-80. PubMed PMID: 236151. 6: Smith M, de Souza MA, Pugliese S, Mari Jde J. In vivo study of the mutagenicity of biperidine, pipotiazine, chlorpromazine, and haloperidol. Am J Med Genet. 1996 Apr 9;67(2):238. PubMed PMID: 8723058. 7: Hyrman V. Pipotiazine palmitate, a long acting drug, indeed: a case report. Can J Psychiatry. 1985 Apr;30(3):221-2. PubMed PMID: 2859922.