Difenamizole HCl | CAS# 20170-21-2 (HCl) | non-steroidal anti-inflammatory drug (NSAID) and analgesic

MedKoo Cat#: 413721 | Name: Difenamizole HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Difenamizole HCl is the salt form of Difenamizole, a non-steroidal anti-inflammatory drug (NSAID) and analgesic of the pyrazolone group related to metamizole. It has monoaminergic properties, including inhibition of monoamine oxidase, augmentation of pargyline-induced elevation of striatal dopamine levels, inhibition of K+-induced striatal dopamine release, and inhibition of the reuptake of dopamine.

Chemical Structure

Difenamizole HCl

CAS#20170-21-2 (HCl)

Theoretical Analysis

MedKoo Cat#: 413721

Name: Difenamizole HCl

CAS#: 20170-21-2 (HCl)

Chemical Formula: C20H23ClN4O

Exact Mass: 370.1560

Molecular Weight: 370.88

Elemental Analysis: C, 64.77; H, 6.25; Cl, 9.56; N, 15.11; O, 4.31

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

20170-20-1 (free base) 20170-21-2 (HCl)

Synonym

Difenamizole HCl; Difenamizole hydrochloride

IUPAC/Chemical Name

Propanamide, 2-(dimethylamino)-N-(1,3-diphenyl-1H-pyrazol-5-yl)-, hydrochloride (9CI)

InChi Key

FEQXCYYOHRHTEH-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H22N4O.ClH/c1-15(23(2)3)20(25)21-19-14-18(16-10-6-4-7-11-16)22-24(19)17-12-8-5-9-13-17;/h4-15H,1-3H3,(H,21,25);1H

SMILES Code

CC(N(C)C)C(NC1=CC(C2=CC=CC=C2)=NN1C3=CC=CC=C3)=O.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 370.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Karrouchi K, Radi S, Ramli Y, Taoufik J, Mabkhot YN, Al-Aizari FA, Ansar M. Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review. Molecules. 2018 Jan 12;23(1):134. doi: 10.3390/molecules23010134. PMID: 29329257; PMCID: PMC6017056. 2: Bennani FE, Doudach L, Cherrah Y, Ramli Y, Karrouchi K, Ansar M, Faouzi MEA. Overview of recent developments of pyrazole derivatives as an anticancer agent in different cell line. Bioorg Chem. 2020 Apr;97:103470. doi: 10.1016/j.bioorg.2019.103470. Epub 2019 Dec 14. PMID: 32120072. 3: Kameyama T, Nabeshima T. Effects of 1,3-diphenyl-5-(2-dimethylaminopropionamide)-pyrazole[difenamizole] on a conditioned avoidance response. Neuropharmacology. 1978 Apr-May;17(4-5):249-56. doi: 10.1016/0028-3908(78)90108-9. PMID: 652137. 4: Nabeshima T, Yamaguchi K, Kameyama T. Effects of difenamizole on content of catecholamines and metabolites in mouse brain. Jpn J Pharmacol. 1978 Aug;28(4):642-6. doi: 10.1254/jjp.28.642. PMID: 732046. 5: Kameyama T, Nabeshima T, Yoshida N, Yamaguchi K. Neurochemical studies of an analgesic, 1,3-diphenyl-5-(2-dimethylaminopropionamide)-pyrazole [difenamizole]. Res Commun Chem Pathol Pharmacol. 1981 Jan;31(1):31-53. PMID: 6454942. 6: Kameyama T, Nabeshima T. [Relationship between biogenic amines and analgesic action of difenamizole in heat induced reflexes]. Nihon Yakurigaku Zasshi. 1976 Jul;72(5):543-56. Japanese. doi: 10.1254/fpj.72.543. PMID: 136390. 7: Nabeshima T, Kameyama T. [Effects of difenamizole on behavior maintained by schedule of positive reinforcement (author's transl)]. Nihon Yakurigaku Zasshi. 1977 Nov;73(8):961-72. Japanese. doi: 10.1254/fpj.73.961. PMID: 611070. 8: Nabeshima T, Ina M, Kameyama T. [Effect of monoamine-related drugs on inhibitory action of difenamizole to acetic acid-induced writhing in mice (author's transl)]. Nihon Yakurigaku Zasshi. 1977 Nov;73(8):907-17. Japanese. doi: 10.1254/fpj.73.907. PMID: 611067. 9: Kameyama T, Ukai M, Nabeshima T. Inhibitory effect of difenamizole on morphine-induced straub tail reaction with special reference to monoaminergic agents. Chem Pharm Bull (Tokyo). 1978 Nov;26(11):3265-70. doi: 10.1248/cpb.26.3265. PMID: 729114.