MedKoo Cat#: 319664 | Name: Aftobetin HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Aftobetin, also known as ANCA11 and NCE-11, is a novel amyloid–binding compound applied topically in the form of an ophthalmic ointment. Aftobetin may be of useful as an aid in the diagnosis Alzheimer's disease.

Chemical Structure

Aftobetin HCl
Aftobetin HCl
CAS#1353222-83-9 (HCl)

Theoretical Analysis

MedKoo Cat#: 319664

Name: Aftobetin HCl

CAS#: 1353222-83-9 (HCl)

Chemical Formula: C26H33ClN2O5

Exact Mass: 0.0000

Molecular Weight: 489.01

Elemental Analysis: C, 63.86; H, 6.80; Cl, 7.25; N, 5.73; O, 16.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
ANCA11; ANCA11; ANCA11; NCE-11; NCE11; NCE 11; Compound #11, Aftobetin; Aftobetin Hydrochloride; Aftobetin HCl.
IUPAC/Chemical Name
2-(2-(2-methoxyethoxy)ethoxy)ethyl (E)-2-cyano-3-(6-(piperidin-1-yl)naphthalen-2-yl)acrylate hydrochloride
InChi Key
GMWHTUNMFTUKHH-NDUABGMUSA-N
InChi Code
InChI=1S/C26H32N2O5.ClH/c1-30-11-12-31-13-14-32-15-16-33-26(29)24(20-27)18-21-5-6-23-19-25(8-7-22(23)17-21)28-9-3-2-4-10-28;/h5-8,17-19H,2-4,9-16H2,1H3;1H/b24-18+;
SMILES Code
O=C(OCCOCCOCCOC)/C(C#N)=C/C1=CC=C2C=C(N3CCCCC3)C=CC2=C1.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Related: 1353222-83-9 (Aftobetin HCl salt) 1208971-05-4 (Aftobetin free base).

Preparing Stock Solutions

The following data is based on the product molecular weight 489.01 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Li Y, Liu X, Liu Q, Wang Y, Liu C, Chen F. Green Synthesis of Alzheimer's Disease Probes Aftobetin and Analogues Enabled by Flow Technology and Heterogeneous Photocatalysis. ChemSusChem. 2025 Jan 2;18(1):e202401214. doi: 10.1002/cssc.202401214. Epub 2024 Sep 6. PMID: 39031513.