MedKoo Cat#: 591331 | Name: Aftobetin free base
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Aftobetin, also known as ANCA11 and NCE-11, is a novel amyloid–binding compound applied topically in the form of an ophthalmic ointment. Aftobetin may be of useful as an aid in the diagnosis Alzheimer's disease.

Chemical Structure

Aftobetin free base
Aftobetin free base
CAS#1208971-05-4 (free base)

Theoretical Analysis

MedKoo Cat#: 591331

Name: Aftobetin free base

CAS#: 1208971-05-4 (free base)

Chemical Formula: C26H32N2O5

Exact Mass: 452.2311

Molecular Weight: 452.55

Elemental Analysis: C, 69.01; H, 7.13; N, 6.19; O, 17.68

Price and Availability

Size Price Availability Quantity
5mg USD 250.00 Ready to Ship
10mg USD 450.00 Ready to Ship
25mg USD 750.00 Ready to Ship
50mg USD 1,250.00 Ready to Ship
100mg USD 2,150.00 Ready to Ship
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Synonym
Aftobetin; ANCA11; ANCA11; ANCA11; NCE-11; NCE11; NCE 11; Compound #11, Aftobetin;
IUPAC/Chemical Name
2-(2-(2-Methoxyethoxy)ethoxy)ethyl (2E)-2-cyano-3-(6-(piperidin-1-yl)naphthalen-2-yl)prop-2-enoate
InChi Key
NRZNTGUFHSJBTD-HKOYGPOVSA-N
InChi Code
InChI=1S/C26H32N2O5/c1-30-11-12-31-13-14-32-15-16-33-26(29)24(20-27)18-21-5-6-23-19-25(8-7-22(23)17-21)28-9-3-2-4-10-28/h5-8,17-19H,2-4,9-16H2,1H3/b24-18+
SMILES Code
O=C(OCCOCCOCCOC)/C(C#N)=C/C1=CC=C2C=C(N3CCCCC3)C=CC2=C1
Appearance
Viscous liquid
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Biological target:
Aftobetin, also known as ANCA11 and NCE-11, is a novel amyloid–binding compound applied topically in the form of an ophthalmic ointment.
In vitro activity:
This chapter presents protocols for the synthesis and use of ANCA-11 as an environmentally-sensitive amyloid-targeting probe that can fluorescently discriminate between amyloids with different disease origin. Reference: Methods Enzymol. 2020;639:91-114. https://pubmed.ncbi.nlm.nih.gov/32475414/
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 452.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Teppang KL, Ehrlich RS, Yang J. Method to discriminate amyloids using fluorescent probes. Methods Enzymol. 2020;639:91-114. doi: 10.1016/bs.mie.2020.04.010. Epub 2020 Apr 25. PMID: 32475414.
In vitro protocol:
1. Teppang KL, Ehrlich RS, Yang J. Method to discriminate amyloids using fluorescent probes. Methods Enzymol. 2020;639:91-114. doi: 10.1016/bs.mie.2020.04.010. Epub 2020 Apr 25. PMID: 32475414.
In vivo protocol:
TBD
Li Y, Liu X, Liu Q, Wang Y, Liu C, Chen F. Green Synthesis of Alzheimer's Disease Probes Aftobetin and Analogues Enabled by Flow Technology and Heterogeneous Photocatalysis. ChemSusChem. 2025 Jan 2;18(1):e202401214. doi: 10.1002/cssc.202401214. Epub 2024 Sep 6. PMID: 39031513.