D-DOPA is the dextrorotary isomer of the dopamine precursor L-DOPA. It can be converted to L-DOPA via sequential oxidation and transamination, which are mediated by D-amino acid oxidase and DOPA transaminase, respectively, in rat kidney homogenates. It reduces the number of dopaminergic neurons in primary rat embryonic mesencephalic cultures in a concentration-dependent manner. Intraventricular administration of D-DOPA increases striatal dopamine levels in rats. D-DOPA induces contralateral turns in a rat model of Parkinson's disease induced by 6-OHDA.
MedKoo Cat#: 462883
Name: D-DOPA
CAS#: 5796-17-8
Chemical Formula: C9H11NO4
Exact Mass: 197.0688
Molecular Weight: 197.19
Elemental Analysis: C, 54.82; H, 5.62; N, 7.10; O, 32.45
The following data is based on the product molecular weight 197.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
