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MedKoo Cat#: 317535 | Name: Ciprofloxacin Hydrochloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ciprofloxacin hydrochloride is a broad-spectrum antimicrobial carboxyfluoroquinoline, an fluoroquinolone antibiotic that is widely used as an antimicrobial and immunomodulatory agent. It is capable of inducing respiratory, urinary tract, gastrointestinal, and abdominal infections. It functions by inhibiting DNA gyrase (a type II topoisomerase) and topoisomerase IV, the enzymes responsible for negative supercoiling of chromosomes and DNA strand separation, thus blocking initiation of bacterial replication. Most recently ciprofloxacin has been used in the management of postexposure inhalational anthrax and radiation combined injury resulting from nuclear disasters.

Chemical Structure

Ciprofloxacin Hydrochloride
CAS#93107-08-5 (HCl)

Theoretical Analysis

MedKoo Cat#: 317535

Name: Ciprofloxacin Hydrochloride

CAS#: 93107-08-5 (HCl)

Chemical Formula: C17H19ClFN3O3

Exact Mass: 0.0000

Molecular Weight: 367.80

Elemental Analysis: C, 55.51; H, 5.21; Cl, 9.64; F, 5.17; N, 11.42; O, 13.05

Price and Availability

Size Price Availability Quantity
5g USD 350.00 2 Weeks
10g USD 550.00 2 Weeks
25g USD 850.00 2 Weeks
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Related CAS #
85721-33-1 (free base) 86393-32-0 (HCl hydrate) 86483-48-9 (xHCl) 93107-08-5 (HCl) 96186-80-0 (lactate) 97867-33-9 (lactate)
Synonym
Ciprofloxacin hydrochloride; Ciloxan; Ceprimax; Oftacilox; Ciprofloxacin hydrochloride monohydrate; Proquin XR; Hydrochloride Anhydrous, Ciprofloxacin; Hydrochloride, Ciprofloxacin; Monohydrate, Ciprofloxacin Monohydrochloride; Monohydrochloride Monohydrate, Ciprofloxacin;
IUPAC/Chemical Name
cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid, monohydrochloride
InChi Key
DIOIOSKKIYDRIQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H18FN3O3.ClH/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24;/h7-10,19H,1-6H2,(H,23,24);1H
SMILES Code
FC1=CC2=C(C=C1N3CCNCC3)N(C4CC4)C=C(C(O)=O)C2=O.Cl
Appearance
White to light yellow crystalline powder.
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 367.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Formulation of ciprofloxacin hydrochloride loaded biodegradable nanoparticles: optimization of technique and process variables. Pharm Dev Technol. 2014 Nov;19(7):891-900. doi: 10.3109/10837450.2013.836293. Epub 2013 Sep 13. PubMed PMID: 24032531. 5: Stojkovic A, Parojcic J, Djuric Z, Corrigan OI. A case study of in silico modelling of ciprofloxacin hydrochloride/metallic compound interactions. AAPS PharmSciTech. 2014 Apr;15(2):270-8. doi: 10.1208/s12249-013-0055-x. Epub 2013 Dec 5. PubMed PMID: 24306676; PubMed Central PMCID: PMC3969494. 6: Gaikwad VD, Yadav VD, Gaikwad MD. Novel sustained release and swellable gastroretentive dosage form for ciprofloxacin hydrochloride. Int J Pharm Investig. 2014 Apr;4(2):88-92. doi: 10.4103/2230-973X.133057. PubMed PMID: 25006553; PubMed Central PMCID: PMC4083538. 7: Singh KP, Chhabra G, Sharma V, Pathak K. Thermosensitive periodontal sol of ciprofloxacin hydrochloride and serratiopeptidase: Pharmaceutical and mechanical analysis. Int J Pharm Investig. 2014 Jan;4(1):5-14. doi: 10.4103/2230-973X.127734. PubMed PMID: 24678456; PubMed Central PMCID: PMC3944617. 8: Yoshikawa T, Takahashi Y, Kawaguchi H, Utsunomiya S, Miura N, Izumi H, Miyoshi N, Tanimoto A. A dermal phototoxicity study following intravenous infusion administration of ciprofloxacin hydrochloride in the novel microminipigs. Toxicol Pathol. 2013 Jan;41(1):109-13. doi: 10.1177/0192623312452489. Epub 2012 Jul 5. PubMed PMID: 22767873. 9: Fahmy R, Kona R, Dandu R, Xie W, Claycamp G, Hoag SW. Quality by design I: Application of failure mode effect analysis (FMEA) and Plackett-Burman design of experiments in the identification of "main factors" in the formulation and process design space for roller-compacted ciprofloxacin hydrochloride immediate-release tablets. AAPS PharmSciTech. 2012 Dec;13(4):1243-54. doi: 10.1208/s12249-012-9844-x. Epub 2012 Sep 20. PubMed PMID: 22993122; PubMed Central PMCID: PMC3513475. 10: Başaran B, Bozkir A. Thermosensitive and pH induced in situ ophthalmic gelling system for ciprofloxacin hydrochloride: hydroxypropyl-beta-cyclodextrin complex. Acta Pol Pharm. 2012 Nov-Dec;69(6):1137-47. PubMed PMID: 23285675. 11: Shah M, Agrawal YK, Garala K, Ramkishan A. Solid lipid nanoparticles of a water soluble drug, ciprofloxacin hydrochloride. Indian J Pharm Sci. 2012 Sep;74(5):434-42. doi: 10.4103/0250-474X.108419. PubMed PMID: 23716872; PubMed Central PMCID: PMC3660870. 12: Verma A, Bansal AK, Ghosh A, Pandit JK. Low molecular mass chitosan as carrier for a hydrodynamically balanced system for sustained delivery of ciprofloxacin hydrochloride. Acta Pharm. 2012 Jun;62(2):237-50. doi: 10.2478/v10007-012-0013-2. PubMed PMID: 22750821. 13: Sakamoto T, Portieri A, Arnone DD, Taday PF, Kawanishi T, Hiyama Y. Coating and Density Distribution Analysis of Commercial Ciprofloxacin Hydrochloride Monohydrate Tablets by Terahertz Pulsed Spectroscopy and Imaging. J Pharm Innov. 2012 Jun;7(2):87-93. Epub 2012 May 25. PubMed PMID: 22707994; PubMed Central PMCID: PMC3366064. 14: Anand U, Kurup L, Mukherjee S. Deciphering the role of pH in the binding of ciprofloxacin hydrochloride to bovine serum albumin. Phys Chem Chem Phys. 2012 Mar 28;14(12):4250-8. doi: 10.1039/c2cp00001f. Epub 2012 Feb 21. PubMed PMID: 22354288. 15: Shah M, Agrawal Y. Ciprofloxacin hydrochloride-loaded glyceryl monostearate nanoparticle: factorial design of Lutrol F68 and Phospholipon 90G. J Microencapsul. 2012;29(4):331-43. doi: 10.3109/02652048.2011.651498. Epub 2012 Jan 18. PubMed PMID: 22251240. 16: Mostafavi A, Emami J, Varshosaz J, Davies NM, Rezazadeh M. Development of a prolonged-release gastroretentive tablet formulation of ciprofloxacin hydrochloride: pharmacokinetic characterization in healthy human volunteers. Int J Pharm. 2011 May 16;409(1-2):128-36. doi: 10.1016/j.ijpharm.2011.02.035. Epub 2011 Mar 1. PubMed PMID: 21371548. 17: Mahrouse MA, Elkady EF. Validated spectrophotometric methods for the simultaneous determination of ciprofloxacin hydrochloride and metronidazole in tablets. Chem Pharm Bull (Tokyo). 2011;59(12):1485-93. PubMed PMID: 22130371. 18: Abdelbary G. Ocular ciprofloxacin hydrochloride mucoadhesive chitosan-coated liposomes. Pharm Dev Technol. 2011 Feb;16(1):44-56. doi: 10.3109/10837450903479988. Epub 2009 Dec 21. PubMed PMID: 20025433. 19: Olivera ME, Manzo RH, Junginger HE, Midha KK, Shah VP, Stavchansky S, Dressman JB, Barends DM. Biowaiver monographs for immediate release solid oral dosage forms: ciprofloxacin hydrochloride. J Pharm Sci. 2011 Jan;100(1):22-33. doi: 10.1002/jps.22259. Review. PubMed PMID: 20602455. 20: Tadros MI. Controlled-release effervescent floating matrix tablets of ciprofloxacin hydrochloride: development, optimization and in vitro-in vivo evaluation in healthy human volunteers. Eur J Pharm Biopharm. 2010 Feb;74(2):332-9. doi: 10.1016/j.ejpb.2009.11.010. Epub 2009 Nov 22. PubMed PMID: 19932750.