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MedKoo Cat#: 597869 | Name: Selank

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Selank is a synthetic tuftsin analogue.

Chemical Structure

Selank
CAS#129954-34-3

Theoretical Analysis

MedKoo Cat#: 597869

Name: Selank

CAS#: 129954-34-3

Chemical Formula: C33H57N11O9

Exact Mass: 751.4341

Molecular Weight: 751.88

Elemental Analysis: C, 52.72; H, 7.64; N, 20.49; O, 19.15

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Selank; Selank; TP7; TP 7; TP-7;
IUPAC/Chemical Name
L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-L-proline
InChi Key
JTDTXGMXNXBGBZ-YVHUGQOKSA-N
InChi Code
InChI=1S/C33H57N11O9/c1-19(45)26(35)29(49)41-20(8-2-3-13-34)30(50)44-17-6-11-23(44)28(48)40-21(9-4-14-38-33(36)37)31(51)43-16-5-10-22(43)27(47)39-18-25(46)42-15-7-12-24(42)32(52)53/h19-24,26,45H,2-18,34-35H2,1H3,(H,39,47)(H,40,48)(H,41,49)(H,52,53)(H4,36,37,38)/t19-,20+,21+,22+,23+,24+,26+/m1/s1
SMILES Code
O=C(O)[C@H]1N(C(CNC([C@H]2N(C([C@H](CCCNC(N)=N)NC([C@H]3N(C([C@H](CCCCN)NC([C@H]([C@H](O)C)N)=O)=O)CCC3)=O)=O)CCC2)=O)=O)CCC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 751.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kolomin T, Morozova M, Volkova A, Shadrina M, Andreeva L, Slominsky P, Limborska S, Myasoedov N. The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action. Mol Immunol. 2014 Mar;58(1):50-5. doi: 10.1016/j.molimm.2013.11.002. Epub 2013 Nov 27. PubMed PMID: 24291245. 2: Volkova A, Shadrina M, Kolomin T, Andreeva L, Limborska S, Myasoedov N, Slominsky P. Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Front Pharmacol. 2016 Feb 18;7:31. doi: 10.3389/fphar.2016.00031. eCollection 2016. PubMed PMID: 26924987; PubMed Central PMCID: PMC4757669. 3: Medvedev VE, Tereshchenko ON, Kost NV, Ter-Israelyan AY, Gushanskaya EV, Chobanu IK, Sokolov OY, Myasoedov NF. [Optimization of the treatment of anxiety disorders with selank]. Zh Nevrol Psikhiatr Im S S Korsakova. 2015;115(6):33-40. doi: 10.17116/jnevro20151156133-40. Russian. PubMed PMID: 26356395. 4: Kolik LG, Nadorova AV, Kozlovskaya MM. Efficacy of peptide anxiolytic selank during modeling of withdrawal syndrome in rats with stable alcoholic motivation. Bull Exp Biol Med. 2014 May;157(1):52-5. doi: 10.1007/s10517-014-2490-4. Epub 2014 Jun 10. PubMed PMID: 24913576. 5: Medvedev VE, Tereshchenko ON, Israelian AIu, Chobanu IK, Kost NV, Sokolov OIu, Miasoedov NF. [A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders]. Zh Nevrol Psikhiatr Im S S Korsakova. 2014;114(7):17-22. Russian. PubMed PMID: 25176261. 6: Mjasoedov NF, Andreeva LA, Grigorjeva ME, Obergan TY, Shubina TA, Lyapina LA. The influence of Selank on the parameters of the hemostasis system, lipid profile, and blood sugar level in the course of experimental metabolic syndrome. Dokl Biol Sci. 2014 Sep;458:267-70. doi: 10.1134/S0012496614050020. Epub 2014 Nov 5. PubMed PMID: 25371249. 7: Kolik LG, Nadorova AV, Seredenin SB. Selank Inhibits Ethanol-Induced Hyperlocomotion and Manifestation of Behavioral Sensitization in DBA/2 Mice. Bull Exp Biol Med. 2016 Nov;162(1):56-59. Epub 2016 Nov 23. PubMed PMID: 27878720. 8: Kozlovskiĭ II, Andreeva LA, Kozlovskaia MM, Nadorova AV, Kolik LG. [The role of opioid system in peculiarities of anti-anxiety effect of peptide anxiolytic selank]. Eksp Klin Farmakol. 2012;75(2):10-3. Russian. PubMed PMID: 22550852. 9: Kolomin TA, Agapova TIu, Agniullin IaV, Shram SI, Shadrina MI, Slominskiĭ PA, Limborskaia SA, Miasoedov IF. [Transcriptome alteration in hippocampus under the treatment of tuftsin analog Selank]. Zh Vyssh Nerv Deiat Im I P Pavlova. 2013 May-Jun;63(3):365-74. Russian. PubMed PMID: 24450168. 10: Kolomin T, Shadrina M, Andreeva L, Slominsky P, Limborska S, Myasoedov N. Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank. Regul Pept. 2011 Oct 10;170(1-3):18-23. doi: 10.1016/j.regpep.2011.05.001. Epub 2011 May 24. PubMed PMID: 21609736. 11: Kolomin TA, Shadrina MI, Slominskiĭ PA, Limborskaia S, Miasoedov NF. [Changes in expression of the genes for chemokines, cytokines, and their receptors in response to selank and its fragments]. Genetika. 2011 May;47(5):711-4. Russian. PubMed PMID: 21786679. 12: Vasil'eva EV, Kondrakhin EA, Salimov RM, Kovalev GI. [COMPARISON OF PHARMACOLOGICAL EFFECTS OF HEPTAPEPTIDE SELANK AFTER INTRANASAL AND INTRAPERITONEAL ADMINISTRATION TO BALB/c AND C57BL/6 MICE.]. Eksp Klin Farmakol. 2016;79(9):3-11. Russian. PubMed PMID: 29787664. 13: Solov'ev VB, Gengin MT, Sollertinskaia TN, Latynova IV, Zhivaeva LV. [Effect of selank on the main carboxypeptidases in the rat nervous tissue]. Zh Evol Biokhim Fiziol. 2012 May-Jun;48(3):254-7. Russian. PubMed PMID: 22827026. 14: Semenova TP, Kozlovskiĭ II, Zakharova NM, Kozlovskaia MM. [Experimental optimization of learning and memory processes by selank]. Eksp Klin Farmakol. 2010 Aug;73(8):2-5. Russian. PubMed PMID: 20919548. 15: Kozlovskiĭ II, Belozertsev FIu, Andreeva LA, Kozlovskaia MM. [Protective effect of selank on the model of mnestic function violation induced by pharmacological blockade of protein synthesis]. Eksp Klin Farmakol. 2013;76(12):3-7. Russian. PubMed PMID: 24605419. 16: [Compensatory and antiamnestic effects of heptapeptide Selank in monkeys]. Zh Evol Biokhim Fiziol. 2008 May-Jun;44(3):284-90. Russian. PubMed PMID: 18727417. 17: Uchakina ON, Uchakin PN, Miasoedov NF, Andreeva LA, Shcherbenko VE, Mezentseva MV, Gabaeva MV, Sokolov OIu, Zozulia AA, Ershov FI. [Immunomodulatory effects of selank in patients with anxiety-asthenic disorders]. Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(5):71-5. Russian. PubMed PMID: 18577961. 18: Semenova TP, kozlovskiĭ II, Zakharova NM, Kozlovskaia MM. [Comparison of the effects of selank and tuftsin on the metabolism of serotonin in the brain of rats pretreated with PCPA]. Eksp Klin Farmakol. 2009 Jul-Aug;72(4):6-8. Russian. PubMed PMID: 19803361. 19: Narkevich VB, Kudrin VS, Klodt PM, Pokrovskiĭ AA, Kozlovskaia MM, Maĭskiĭ AI, Raevskiĭ KS. [Effects of heptapeptide selank on the content of monoamines and their metabolites in the brain of BALB/C and C57Bl/6 mice: a comparative study]. Eksp Klin Farmakol. 2008 Sep-Oct;71(5):8-12. Russian. PubMed PMID: 19093364. 20: Ershov FI, Uchakin PN, Uchakina ON, Mezentseva MV, Alekseeva LA, Miasoedov NF. [Antiviral activity of immunomodulator Selank in experimental influenza infection]. Vopr Virusol. 2009 Sep-Oct;54(5):19-24. Russian. PubMed PMID: 19882898.

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