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MedKoo Cat#: 145227 | Name: BMY-25551

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BMY-25551 is a mitomycin (MMC) derivative. BMY-25551 has been shown to be 8 to 20 times more potent than mitomycin C (MMC) in cytotoxicity to murine and human tumor cell lines. BMY-25551 appears to be more effective in tumor inhibition than MMC against P388 leukemia and B16 melanoma in mice. BMY-25551 is comparable to MMC in hematologic depression in mice.

Chemical Structure

BMY-25551
CAS#105139-98-8

Theoretical Analysis

MedKoo Cat#: 145227

Name: BMY-25551

CAS#: 105139-98-8

Chemical Formula: C17H21N3O7

Exact Mass: 379.1380

Molecular Weight: 379.37

Elemental Analysis: C, 53.82; H, 5.58; N, 11.08; O, 29.52

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
BMY-25551; BMY25551; BMY 25551;
IUPAC/Chemical Name
((1aS,8S,8aR,8bS)-6-(2-hydroxyethoxy)-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazirino[2',3':3,4]pyrrolo[1,2-a]indol-8-yl)methyl carbamate
InChi Key
YJHYHDSHHWKEIS-CJUKMMNNSA-N
InChi Code
1S/C17H21N3O7/c1-7-12(22)11-10(13(23)14(7)26-4-3-21)8(6-27-16(18)24)17(25-2)15-9(19-15)5-20(11)17/h8-9,15,19,21H,3-6H2,1-2H3,(H2,18,24)/t8-,9+,15+,17-/m1/s1
SMILES Code
[H][C@]12CN3C4=C([C@@H](COC(N)=O)[C@@]3(OC)[C@@]1([H])N2)C(=O)C(OCCO)=C(C)C4=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 379.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bregman CL, Buroker RA, Bradner WT, Hirth RS, Madissoo H. Cardiac, renal, and pulmonary toxicity of several mitomycin derivatives in rats. Fundam Appl Toxicol. 1989 Jul;13(1):46-64. doi: 10.1016/0272-0590(89)90306-0. PMID: 2767361. 2: Bradner WT, Catino JJ, Long BH, Rose WC, Schurig JE. Experimental tumor inhibitory and toxic properties of the mitomycin A analogue 7-(2-hydroxyethoxy) mitosane (BMY-25551). Anticancer Res. 1992 May-Jun;12(3):959-64. PMID: 1622154.