MedKoo Cat#: 318961 | Name: Trovafloxacin mesylate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Trovafloxacin was a broad spectrum antibiotic that inhibits the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was withdrawn from the market due to the risk of hepatotoxicity. It had better gram-positive bacterial coverage and less gram-negative coverage than the previous fluoroquinolones.

Chemical Structure

Trovafloxacin mesylate
Trovafloxacin mesylate
CAS#147059-75-4 (mesylate)

Theoretical Analysis

MedKoo Cat#: 318961

Name: Trovafloxacin mesylate

CAS#: 147059-75-4 (mesylate)

Chemical Formula: C21H19F3N4O6S

Exact Mass:

Molecular Weight: 512.46

Elemental Analysis: C, 49.22; H, 3.74; F, 11.12; N, 10.93; O, 18.73; S, 6.26

Price and Availability

Size Price Availability Quantity
10mg USD 350.00
50mg USD 1,090.00 2 Weeks
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Related CAS #
147059-75-4 (mesylate) 147059-72-1 (free base)
Synonym
CP-99219; CP 99219; CP99219; CP 99,219; CP 99219; CP-99,219; Trovafloxacin mesylate; Band name: Trovan;Turvel.
IUPAC/Chemical Name
7-[(1S,5R)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid methanesulfonic acid
InChi Key
DYNZICQDCVYXFW-GIPYJWDTSA-N
InChi Code
InChI=1S/C20H15F3N4O3.CH4O3S/c21-8-1-2-15(13(22)3-8)27-7-12(20(29)30)17(28)9-4-14(23)19(25-18(9)27)26-5-10-11(6-26)16(10)24;1-5(2,3)4/h1-4,7,10-11,16H,5-6,24H2,(H,29,30);1H3,(H,2,3,4)/t10-,11+,16?;
SMILES Code
O=C(C1=CN(C2=CC=C(F)C=C2F)C3=NC(N4C[C@@]5([H])C(N)[C@@]5([H])C4)=C(F)C=C3C1=O)O.CS(=O)(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Related CAS# CAS#147059-75-4 ( Trovafloxacin mesylate) CAS#147059-72-1 ( Trovafloxacin free base).

Preparing Stock Solutions

The following data is based on the product molecular weight 512.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Shaw PJ, Ganey PE, Roth RA. Idiosyncratic drug-induced liver injury and the role of inflammatory stress with an emphasis on an animal model of trovafloxacin hepatotoxicity. Toxicol Sci. 2010 Nov;118(1):7-18. doi: 10.1093/toxsci/kfq168. Epub 2010 Jun 10. Review. PubMed PMID: 20538741; PubMed Central PMCID: PMC2955207. 2: Mandell LA. [The role of trovafloxacin in the treatment of nosocomial pneumonia]. Medicina (B Aires). 1999;59 Suppl 1:39-46. Review. Spanish. PubMed PMID: 10436553. 3: Azanza JR, Ollero D, Sádaba B, García Quetglas E. [Trovafloxacin]. Rev Med Univ Navarra. 1999 Jan-Mar;43(1):45-57. Review. Spanish. PubMed PMID: 10386346. 4: Garau J. [Is trovafloxacin an antibiotic exclusively for the treatment of respiratory infections?]. Enferm Infecc Microbiol Clin. 1998 Dec;16 Suppl 2:43-6; discussion 47-52. Review. Spanish. PubMed PMID: 10344098. 5: Frías J, de los Angeles Gálvez M. [Pharmacokinetics and safety of trovafloxacin]. Enferm Infecc Microbiol Clin. 1998 Dec;16 Suppl 2:36-42; discussion 47-52. Review. Spanish. PubMed PMID: 10344097. 6: Alghasham AA, Nahata MC. Trovafloxacin: a new fluoroquinolone. Ann Pharmacother. 1999 Jan;33(1):48-60. Review. PubMed PMID: 9972385. 7: Garey KW, Amsden GW. Trovafloxacin: an overview. Pharmacotherapy. 1999 Jan;19(1):21-34. Review. PubMed PMID: 9917076. 8: Pechère JC, Gootz TD. Bacteriological activity of trovafloxacin, a new quinolone, against respiratory tract pathogens. Eur J Clin Microbiol Infect Dis. 1998 Jun;17(6):405-12. Review. PubMed PMID: 9758283. 9: McNabb J, Nicolau D, Quintiliani R, Nightingale C. Trovafloxacin: fourth generation fluoroquinolone. Conn Med. 1998 Aug;62(8):483-7. Review. PubMed PMID: 9753805. 10: Ernst ME, Ernst EJ, Klepser ME. Levofloxacin and trovafloxacin: the next generation of fluoroquinolones? Am J Health Syst Pharm. 1997 Nov 15;54(22):2569-84. Review. PubMed PMID: 9397218. 11: Haria M, Lamb HM. Trovafloxacin. Drugs. 1997 Sep;54(3):435-45; discussion 446. Review. PubMed PMID: 9279505. 12: Brighty KE, Gootz TD. The chemistry and biological profile of trovafloxacin. J Antimicrob Chemother. 1997 Jun;39 Suppl B:1-14. Review. PubMed PMID: 9222064. 13: Goldstein EJ. Possible role for the new fluoroquinolones (levofloxacin, grepafloxacin, trovafloxacin, clinafloxacin, sparfloxacin, and DU-6859a) in the treatment of anaerobic infections: review of current information on efficacy and safety. Clin Infect Dis. 1996 Dec;23 Suppl 1:S25-30. Review. PubMed PMID: 8953103.