MedKoo Cat#: 564353 | Name: KIST301072

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KIST301072 is a ROS1 kinase inhibitor.

Chemical Structure

KIST301072
KIST301072
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564353

Name: KIST301072

CAS#: NONE

Chemical Formula: C26H25N5O2

Exact Mass: 439.2008

Molecular Weight: 439.52

Elemental Analysis: C, 71.05; H, 5.73; N, 15.93; O, 7.28

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
KIST-301072; KIST 301072; KIST301072
IUPAC/Chemical Name
(S)-2-(3-(3-Hydroxy-5-methylphenyl)-4-(6-(3-hydroxybutyl)-[2,3'-bipyridin]-4-yl)-1H-pyrazol-1-yl)acetonitrile
InChi Key
JFOVZFUZCSOSNL-SFHVURJKSA-N
InChi Code
InChI=1S/C26H25N5O2/c1-17-10-21(13-23(33)11-17)26-24(16-31(30-26)9-7-27)20-12-22(6-5-18(2)32)29-25(14-20)19-4-3-8-28-15-19/h3-4,8,10-16,18,32-33H,5-6,9H2,1-2H3/t18-/m0/s1
SMILES Code
N#CCN1N=C(C2=CC(C)=CC(O)=C2)C(C3=CC(C4=CC=CN=C4)=NC(CC[C@@H](O)C)=C3)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 439.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Abdelazem AZ, Lee SH. Synthesis and biological evaluation of new pyrimidine-4-yl-ethanol derivatives as ROS1 kinase inhibitors. J Enzyme Inhib Med Chem. 2015 Apr;30(2):290-8. doi: 10.3109/14756366.2014.920838. Epub 2014 Jun 18. PubMed PMID: 24939104. 2: Abdelazem AZ, Al-Sanea MM, Park BS, Park HM, Yoo KH, Sim T, Park JB, Lee SH, Lee SH. Synthesis and biological evaluation of new pyrazol-4-ylpyrimidine derivatives as potential ROS1 kinase inhibitors. Eur J Med Chem. 2015 Jan 27;90:195-208. doi: 10.1016/j.ejmech.2014.11.023. Epub 2014 Nov 13. PubMed PMID: 25461320.