RP-72540, also known as RPR-102681, is a cholecystokinin B receptor antagonist potentially for the treatment of cocaine abuse. RP 72540 showed selectivity factors in express of 200 for CCKB versus CCKA receptors and also had high affinity for gastrin binding sites in the stomach. Administration of RP-72540 resulted in a dose-dependent inhibition of [3H]pCCK-8 binding in mouse brain homogenate. However, the relative penetration of RP-72540 into the forebrain after peripheral administration was below 0.01%.
MedKoo Cat#: 528102
Name: RP-72540
CAS#: 139088-45-2
Chemical Formula: C28H30N4O6
Exact Mass: 518.2165
Molecular Weight: 518.57
Elemental Analysis: C, 64.85; H, 5.83; N, 10.80; O, 18.51
The following data is based on the product molecular weight 518.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
