Synonym
Hexamide; Benzimine; Benzimin; 1-Benzoylperhydroazepine; N-Benzoylhexahydroazepine
IUPAC/Chemical Name
azepan-1-yl(phenyl)methanone
InChi Key
KZLCCMBSJDXNDG-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H17NO/c15-13(12-8-4-3-5-9-12)14-10-6-1-2-7-11-14/h3-5,8-9H,1-2,6-7,10-11H2
SMILES Code
O=C(N1CCCCCC1)C2=CC=CC=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
203.28
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Shibata S, Satake N, Sato N, Matsuo M, Koibuchi Y, Hester RK. Characteristics of the vasorelaxing action of (3E)-4-ethyl-2-hydroximino-5-nitro-3-hexamide FK409, a new vasodilator isolated from microbial sources, in isolated rabbit arteries. J Cardiovasc Pharmacol. 1991 Mar;17(3):508-18. PubMed PMID: 1711615.
2: SERICK E, STILLE G, WALTER O, WOLF V. [Excretion of hexamide]. Arztl Forsch. 1957 May 10;11(5):I/264-5. German. PubMed PMID: 13435063.
3: RIESCHEL G. [Possibilities of treatment of extrasystolic paroxysmal tachycardia with hexamide]. Arztl Wochensch. 1957 Sep 27;12(39):874-6. German. PubMed PMID: 13497898.
4: BERNHAUER K, WAGNER F. [Syntheses in the vitamin B12 group. IX. On the synthesis of cobyrinyl-abcdeg-hexamide-f-N-DL-serine phosphate and cobyrinyl-abcdeg-f-N-DL-threonine phosphate and the biosynthetic evaluation of some cobinamide analogs]. Biochem Z. 1962;335:325-39. German. PubMed PMID: 13868165.
5: SCHMUTZLER R. [First clinical experience in internal medicine with hexamide]. Medizinische. 1957 Oct 19;2(42):1532-6. Undetermined Language. PubMed PMID: 13482914.
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8: Mathis C, Lehmann J, Ungerer A. The selective protein kinase C inhibitor, NPC 15437, induces specific deficits in memory retention in mice. Eur J Pharmacol. 1992 Sep 10;220(1):107-10. PubMed PMID: 1425976.
9: Chen YJ, Jiang H, Quilley J. The nitric oxide- and prostaglandin-independent component of the renal vasodilator effect of thimerosal is mediated by epoxyeicosatrienoic acids. J Pharmacol Exp Ther. 2003 Mar;304(3):1292-8. PubMed PMID: 12604709.
10: Casnati A, Barboso S, Rouquette H, Schwing-Weill MJ, Arnaud-Neu F, Dozol JF, Ungaro R. New efficient calixarene amide ionophores for the selective removal of strontium ion from nuclear waste: synthesis, complexation, and extraction properties. J Am Chem Soc. 2001 Dec 12;123(49):12182-90. PubMed PMID: 11734017.
