MedKoo Cat#: 317162 | Name: Albendazole
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Albendazole is an oral medication used for the treatment of a variety of parasitic worm infestations. It is useful for giardiasis, trichuriasis, filariasis, neurocysticercosis, hydatid disease, pinworm disease, and ascariasis, among others. Albendazole is a broad-spectrum antihelminthic agent of the benzimidazole type. Albendazole came into use in 1971. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.

Chemical Structure

Albendazole
Albendazole
CAS#54965-21-8

Theoretical Analysis

MedKoo Cat#: 317162

Name: Albendazole

CAS#: 54965-21-8

Chemical Formula: C12H15N3O2S

Exact Mass: 265.0885

Molecular Weight: 265.33

Elemental Analysis: C, 54.32; H, 5.70; N, 15.84; O, 12.06; S, 12.08

Price and Availability

Size Price Availability Quantity
1g USD 90.00 Ready to ship
2g USD 165.00 Ready to ship
5g USD 350.00 Ready to ship
10g USD 550.00 Ready to ship
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Synonym
Albendazole; Eskazole; Zentel; Albenza; Valbazen
IUPAC/Chemical Name
methyl (5-(propylthio)-1H-benzo[d]imidazol-2-yl)carbamate
InChi Key
HXHWSAZORRCQMX-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
SMILES Code
O=C(OC)NC1=NC2=CC(SCCC)=CC=C2N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Certificate of Analysis
Safety Data Sheet (SDS)
Biological target:
Albendazole is a broad-spectrum parasiticide with high effectiveness and low host toxicity that is used for the research gastrointestinal parasites in humans and animals.
In vitro activity:
In the present study, the anticancer effects of albendazole on prostate cancer cells were assessed using proliferation, clonogenic and migration assays. ROS production was measured in both PC3 and DU145 cells 24 h after albendazole treatment, using the fluorescent dye, DCFH-DA. Compared with the control, albendazole increased intracellular ROS levels in a concentration-dependent manner. Furthermore, oxidative stress regulates Wnt/β-catenin signaling, and albendazole was shown to decrease the mRNA expression of CTNNB and TCF4, genes that regulate Wnt/β-catenin signaling. In DU145 cells, both 0.1 and 0.5 µM albendazole decreased the mRNA expression of CTNNB1 and TCF4, whereas in PC3 cells only 0.5 µM albendazole decreased the expression of TCF4. The mRNA expression of CTNNB1 decreased at 0.1 and 0.5 µM albendazole in PC3 cells. These results suggest that the antihelmintic drug, albendazole, has inhibitory effects against prostate cancer cells in vitro. Reference: Oncol Lett. 2021 May; 21(5): 395. https://pubmed.ncbi.nlm.nih.gov/33777218/
In vivo activity:
Mice were inoculated with Echinococcus multilocularis intrahepatically to develop the hepatic AE (alveolar echinococcosis) murine model. Oral albendazole administration was then applied for three months after the first inoculation. Among the 17 cytokines and chemokines detected, plasma levels of IL-23 were significantly higher in E. multilocularis-infected mice when compared to the control group; furthermore, more obvious increasing levels were found after albendazole treatment (p < 0.05). All chemokine levels other than eotaxin and MCP-3 were slightly higher in E. multilocularis-infected mice compared to the control group (p > 0.05). Eotaxin levels were significantly decreased in mice with E. multilocularis infection followed by albendazole treatment (p < 0.05). Both IL-17A and IL-23 expressions in hepatic AE lesions were significantly higher and related with disease activity. In conclusion, Albendazole administration influenced the balance of immune response and promotes the secretion of proinflammatory factors which is beneficial to parasite clearance. Reference: Biomed Res Int. 2021 May 7;2021:6628814. https://pubmed.ncbi.nlm.nih.gov/34041299/
Solvent mg/mL mM
Solubility
DMSO 15.7 59.10
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 265.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Kim U, Shin C, Kim CY, Ryu B, Kim J, Bang J, Park JH. Albendazole exerts antiproliferative effects on prostate cancer cells by inducing reactive oxygen species generation. Oncol Lett. 2021 May;21(5):395. doi: 10.3892/ol.2021.12656. Epub 2021 Mar 18. PMID: 33777218; PMCID: PMC7988661. 2. Wang LJ, Liou LR, Shi YJ, Chiou JT, Lee YC, Huang CH, Huang PW, Chang LS. Albendazole-Induced SIRT3 Upregulation Protects Human Leukemia K562 Cells from the Cytotoxicity of MCL1 Suppression. Int J Mol Sci. 2020 May 30;21(11):3907. doi: 10.3390/ijms21113907. PMID: 32486166; PMCID: PMC7312678. 3.Wu J, Ma HZ, Apaer S, Anweier N, Zeng Q, Fulati X, Li T, Zhao JM, Wen H, Tuxun T. Impact of Albendazole on Cytokine and Chemokine Response Profiles in Echinococcus multilocularis-Inoculated Mice. Biomed Res Int. 2021 May 7;2021:6628814. doi: 10.1155/2021/6628814. PMID: 34041299; PMCID: PMC8121589. 4.Weingartner M, Stücheli S, Jebbawi F, Gottstein B, Beldi G, Lundström-Stadelmann B, Wang J, Odermatt A. Albendazole reduces hepatic inflammation and endoplasmic reticulum-stress in a mouse model of chronic Echinococcus multilocularis infection. PLoS Negl Trop Dis. 2022 Jan 14;16(1):e0009192. doi: 10.1371/journal.pntd.0009192. PMID: 35030165; PMCID: PMC8794265.
In vitro protocol:
1. Kim U, Shin C, Kim CY, Ryu B, Kim J, Bang J, Park JH. Albendazole exerts antiproliferative effects on prostate cancer cells by inducing reactive oxygen species generation. Oncol Lett. 2021 May;21(5):395. doi: 10.3892/ol.2021.12656. Epub 2021 Mar 18. PMID: 33777218; PMCID: PMC7988661. 2. Wang LJ, Liou LR, Shi YJ, Chiou JT, Lee YC, Huang CH, Huang PW, Chang LS. Albendazole-Induced SIRT3 Upregulation Protects Human Leukemia K562 Cells from the Cytotoxicity of MCL1 Suppression. Int J Mol Sci. 2020 May 30;21(11):3907. doi: 10.3390/ijms21113907. PMID: 32486166; PMCID: PMC7312678.
In vivo protocol:
1. Wu J, Ma HZ, Apaer S, Anweier N, Zeng Q, Fulati X, Li T, Zhao JM, Wen H, Tuxun T. Impact of Albendazole on Cytokine and Chemokine Response Profiles in Echinococcus multilocularis-Inoculated Mice. Biomed Res Int. 2021 May 7;2021:6628814. doi: 10.1155/2021/6628814. PMID: 34041299; PMCID: PMC8121589. 2. Weingartner M, Stücheli S, Jebbawi F, Gottstein B, Beldi G, Lundström-Stadelmann B, Wang J, Odermatt A. Albendazole reduces hepatic inflammation and endoplasmic reticulum-stress in a mouse model of chronic Echinococcus multilocularis infection. PLoS Negl Trop Dis. 2022 Jan 14;16(1):e0009192. doi: 10.1371/journal.pntd.0009192. PMID: 35030165; PMCID: PMC8794265.
1: PLOS Neglected Tropical Diseases Staff. Correction: Efficacy of Albendazole-Chitosan Microsphere-based Treatment for Alveolar Echinococcosis in Mice. PLoS Negl Trop Dis. 2015 Oct 29;9(10):e0004181. doi: 10.1371/journal.pntd.0004181. eCollection 2015 Oct. PubMed PMID: 26512896. 2: Aboagye-Antwi F, Kwansa-Bentum B, Dadzie SK, Ahorlu CK, Appawu MA, Gyapong J, Wilson MD, Boakye DA. Transmission indices and microfilariae prevalence in human population prior to mass drug administration with ivermectin and albendazole in the Gomoa District of Ghana. Parasit Vectors. 2015 Oct 26;8(1):562. doi: 10.1186/s13071-015-1105-x. PubMed PMID: 26503363; PubMed Central PMCID: PMC4624376. 3: Thomsen EK, Sanuku N, Baea M, Satofan S, Maki E, Lombore B, Schmidt MS, Siba PM, Weil GJ, Kazura JW, Fleckenstein LL, King CL. Efficacy, Safety, and Pharmacokinetics of Co-Administered Diethylcarbamazine, Albendazole, and Ivermectin for the Treatment of Bancroftian Filariasis. Clin Infect Dis. 2015 Oct 20. pii: civ882. [Epub ahead of print] PubMed PMID: 26486704. 4: Escobedo AA, Ballesteros J, González-Fraile E, Almirall P. A meta-analysis of the efficacy of albendazole compared with tinidazole as treatments for Giardia infections in children. Acta Trop. 2015 Oct 14. pii: S0001-706X(15)30121-2. doi: 10.1016/j.actatropica.2015.09.023. [Epub ahead of print] Review. PubMed PMID: 26476393. 5: Romo ML, Wyka K, Carpio A, Leslie D, Andrews H, Bagiella E, Hauser WA, Kelvin EA; Ecuadorian Neurocysticercosis Group. The effect of albendazole treatment on seizure outcomes in patients with symptomatic neurocysticercosis. Trans R Soc Trop Med Hyg. 2015 Nov;109(11):738-46. doi: 10.1093/trstmh/trv078. Epub 2015 Oct 3. PubMed PMID: 26433183. 6: Ortonobes Roig S, López García B, Solano Luque MF, Ferrández Quirante O. [Haematological toxicity during treatment with albendazole]. Enferm Infecc Microbiol Clin. 2015 Sep 29. pii: S0213-005X(15)00288-8. doi: 10.1016/j.eimc.2015.07.013. [Epub ahead of print] Spanish. PubMed PMID: 26432766. 7: Pensel PE, Ullio Gamboa G, Fabbri J, Ceballos L, Sanchez Bruni S, Alvarez LI, Allemandi D, Benoit JP, Palma SD, Elissondo MC. Cystic echinococcosis therapy: Albendazole-loaded lipid nanocapsules enhance the oral bioavailability and efficacy in experimentally infected mice. Acta Trop. 2015 Sep 26;152:185-194. doi: 10.1016/j.actatropica.2015.09.016. [Epub ahead of print] PubMed PMID: 26409727. 8: Chami GF, Kontoleon AA, Bulte E, Fenwick A, Kabatereine NB, Tukahebwa EM, Dunne DW. Profiling Nonrecipients of Mass Drug Administration for Schistosomiasis and Hookworm Infections: A Comprehensive Analysis of Praziquantel and Albendazole Coverage in Community-Directed Treatment in Uganda. Clin Infect Dis. 2015 Sep 25. pii: civ829. [Epub ahead of print] PubMed PMID: 26409064. 9: Belew S, Getachew M, Suleman S, Mohammed T, Deti H, D'Hondt M, Wynendaele E, Mekonnen Z, Vercruysse J, Duchateau L, De Spiegeleer B, Levecke B. Assessment of Efficacy and Quality of Two Albendazole Brands Commonly Used against Soil-Transmitted Helminth Infections in School Children in Jimma Town, Ethiopia. PLoS Negl Trop Dis. 2015 Sep 25;9(9):e0004057. doi: 10.1371/journal.pntd.0004057. eCollection 2015 Sep. PubMed PMID: 26406600; PubMed Central PMCID: PMC4583991. 10: Abulaihaiti M, Wu XW, Qiao L, Lv HL, Zhang HW, Aduwayi N, Wang YJ, Wang XC, Peng XY. Efficacy of Albendazole-Chitosan Microsphere-based Treatment for Alveolar Echinococcosis in Mice. PLoS Negl Trop Dis. 2015 Sep 9;9(9):e0003950. doi: 10.1371/journal.pntd.0003950. eCollection 2015 Sep. PubMed PMID: 26352932; PubMed Central PMCID: PMC4564103.