MedKoo Cat#: 563484 | Name: S3QEL-2
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

S3QEL-2 is a modulator of the retrograde signaling. It acts by strongly mitigating the oxidative stress-induced apoptosis that limits the yield of functional ß-cells from intact islets.

Chemical Structure

S3QEL-2
S3QEL-2
CAS#890888-12-7

Theoretical Analysis

MedKoo Cat#: 563484

Name: S3QEL-2

CAS#: 890888-12-7

Chemical Formula: C19H25N5

Exact Mass: 323.2110

Molecular Weight: 323.44

Elemental Analysis: C, 70.56; H, 7.79; N, 21.65

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
10mg USD 500.00 2 Weeks
25mg USD 850.00 2 Weeks
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Related CAS #
No Data
Synonym
S3QEL-2; S3QEL 2; S3QEL2;
IUPAC/Chemical Name
1-(3,4-dimethylphenyl)-N,N-dipropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
InChi Key
MGIAJZSCNPODRR-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H25N5/c1-5-9-23(10-6-2)18-17-12-22-24(19(17)21-13-20-18)16-8-7-14(3)15(4)11-16/h7-8,11-13H,5-6,9-10H2,1-4H3
SMILES Code
CCCN(CCC)C1=C2C(N(C3=CC=C(C)C(C)=C3)N=C2)=NC=N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMF
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Biological target:
S3QEL-2 inhibits site IIIQo superoxide production (IC50 = 1.7 µM) without altering normal bioenergetics function. It reduced the production of H2O2 during oxidation of glutamate plus malate to 25% of the control level. S3QEL-2 also protects against ROS-induced cell stress in pancreatic β-cells and decreases HIF-1α induction in response to hypoxia.
In vitro activity:
S3QEL-2 was able to protect pancreatic β-cells during isolation and culture. S3QEL-2 enhanced both survival and function of primary pancreatic islets compared with equimolar amounts of EUK-134. S3QEL-2 is a cell-permeant, potent inhibitor of retrograde signaling mediated by superoxide from site IIIQo. Reference: Nat Chem Biol. 2015 Nov;11(11):834-6. https://pubmed.ncbi.nlm.nih.gov/26368590/
In vivo activity:
To be determined
Solvent mg/mL mM
Solubility
DMF 10.0 30.92
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 323.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Orr AL, Vargas L, Turk CN, Baaten JE, Matzen JT, Dardov VJ, Attle SJ, Li J, Quackenbush DC, Goncalves RL, Perevoshchikova IV, Petrassi HM, Meeusen SL, Ainscow EK, Brand MD. Suppressors of superoxide production from mitochondrial complex III. Nat Chem Biol. 2015 Nov;11(11):834-6. doi: 10.1038/nchembio.1910. Epub 2015 Sep 14. PMID: 26368590; PMCID: PMC4618194.
In vitro protocol:
1. Orr AL, Vargas L, Turk CN, Baaten JE, Matzen JT, Dardov VJ, Attle SJ, Li J, Quackenbush DC, Goncalves RL, Perevoshchikova IV, Petrassi HM, Meeusen SL, Ainscow EK, Brand MD. Suppressors of superoxide production from mitochondrial complex III. Nat Chem Biol. 2015 Nov;11(11):834-6. doi: 10.1038/nchembio.1910. Epub 2015 Sep 14. PMID: 26368590; PMCID: PMC4618194.
In vivo protocol:
To be determined
1: Orr AL, Vargas L, Turk CN, Baaten JE, Matzen JT, Dardov VJ, Attle SJ, Li J, Quackenbush DC, Goncalves RL, Perevoshchikova IV, Petrassi HM, Meeusen SL, Ainscow EK, Brand MD. Suppressors of superoxide production from mitochondrial complex III. Nat Chem Biol. 2015 Nov;11(11):834-6. doi: 10.1038/nchembio.1910. Epub 2015 Sep 14. PubMed PMID: 26368590; PubMed Central PMCID: PMC4618194.