GANT61 is a small-molecule inhibitor of glioma-associated oncogene 1 (GLI1)- and GLI2-mediated transcription at the nuclear level that exerts its effect by preventing DNA binding. It has been demonstrated to induce cell death against Ewing's sarcoma family tumor (ESFT) cell lines in a dose-dependent manner.
MedKoo Cat#: 406570
Name: GANT61
CAS#: 500579-04-4
Chemical Formula: C27H35N5
Exact Mass: 429.2893
Molecular Weight: 429.60
Elemental Analysis: C, 75.49; H, 8.21; N, 16.30
Solvent | mg/mL | mM | |
---|---|---|---|
Solubility | |||
Ethanol | 85.0 | 197.86 |
The following data is based on the product molecular weight 429.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |