MedKoo Cat#: 464525 | Name: LY3023703

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LY3023703 is a mPGES-1 inhibitor.

Chemical Structure

LY3023703
LY3023703
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464525

Name: LY3023703

CAS#: unknown

Chemical Formula: C24H23F5N4O2

Exact Mass: 494.1741

Molecular Weight: 494.47

Elemental Analysis: C, 58.30; H, 4.69; F, 19.21; N, 11.33; O, 6.47

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
LY3023703; LY 3023703; LY-3023703;
IUPAC/Chemical Name
2-(difluoromethyl)-5-(isobutyramidomethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)benzamide
InChi Key
SKJRYXSXMMMSIV-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H23F5N4O2/c1-12(2)21(34)30-11-14-4-9-17(20(25)26)18(10-14)22(35)33-23-31-13(3)19(32-23)15-5-7-16(8-6-15)24(27,28)29/h4-10,12,20H,11H2,1-3H3,(H,30,34)(H2,31,32,33,35)
SMILES Code
O=C(NC1=NC(C)=C(C2=CC=C(C(F)(F)F)C=C2)N1)C3=CC(CNC(C(C)C)=O)=CC=C3C(F)F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 494.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Norman BH, Fisher MJ, Schiffler MA, Kuklish SL, Hughes NE, Czeskis BA, Cassidy KC, Abraham TL, Alberts JJ, Luffer-Atlas D. Identification and Mitigation of Reactive Metabolites of 2-Aminoimidazole-Containing Microsomal Prostaglandin E Synthase-1 Inhibitors Terminated Due to Clinical Drug-Induced Liver Injury. J Med Chem. 2018 Mar 8;61(5):2041-2051. doi: 10.1021/acs.jmedchem.7b01806. Epub 2018 Feb 15. PMID: 29425457. 2: Jin Y, Smith CL, Hu L, Campanale KM, Stoltz R, Huffman LG Jr, McNearney TA, Yang XY, Ackermann BL, Dean R, Regev A, Landschulz W. Pharmacodynamic comparison of LY3023703, a novel microsomal prostaglandin e synthase 1 inhibitor, with celecoxib. Clin Pharmacol Ther. 2016 Mar;99(3):274-84. doi: 10.1002/cpt.260. Epub 2015 Nov 25. PMID: 26351780.